Is TGFBR1*6A a Susceptibility Allele for Nonsyndromic Familial Colorectal Neoplasia?
- Denise Daley1,8,
- Wendi Morgan2,
- Susan Lewis2,
- Joseph Willis4,
- Robert C. Elston1,5,
- Sanford D. Markowitz3,5,7 and
- Georgia L. Wiesner2,3,6
- Departments of 1Epidemiology and Biostatistics, 2Genetics, 3Pathology and 4Medicine, 5Case Comprehensive Cancer Center, 6Center for Human Genetics, 7University Hospitals of Cleveland/Case Western Reserve University and Howard Hughes Medical Institute, and Cleveland, Ohio and the 8University of British Columbia, Vancouver, BC, Canada
- Requests for reprints:
Denise Daley, 166 Burrard Building, 1081 Burrard Street, Vancouver, BC, Canada V6Z1Y6. Phone: 604-682-2344; Fax: 604-806-8351. E-mail: ddaley{at}mrl.ubc.ca
Abstract
Our analysis definitely excludes the possibility of the TGFBR1*6A allele increasing the risk of colorectal neoplasia in our sample population. A recent study validating linkage of colorectal cancer to chromosome 9q also excluded the TGFBR1*6A allele as a disease-causing variant in that sample. We conclude that there remains an unidentified susceptibility locus in the region 9q22.2-31.2. (Cancer Epidemiol Biomarkers Prev 2007;16(5):892–4)
Footnotes
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Grant support: USPHS grants U01 CA82901 (S.D. Markowitz), P30CA43703 (Case Western Reserve University/Ireland Comprehensive Cancer Center), K23 1K23CA81308 (G.L. Wiesner), P41 RR0365 and GM28356 (R.C. Elston), and DAMD17-03-1-0289 (D. Daley).
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- Accepted February 21, 2007.
- Received November 16, 2006.
- Revision received February 15, 2007.
