Serum Heat Shock Protein 70 Levels and Lung Cancer Risk: A Case-Control Study Nested in a Large Cohort Study
- Koji Suzuki1,
- Yoshinori Ito1,2,
- Kenji Wakai4,
- Miyuki Kawado5,
- Shuji Hashimoto5,
- Nao Seki6,
- Masahiko Ando7,
- Yoshikazu Nishino8,
- Takaaki Kondo3,
- Yoshiyuki Watanabe9,
- Kotaro Ozasa9,
- Takashi Inoue1,
- Akiko Tamakoshi2 and
- for the Japan Collaborative Cohort Study Group
- 1Departments of Public Health, Fujita Health University School of Health Sciences, Toyoake, Japan; Departments of 2Preventive Medicine/Biostatistics and Medical Decision Making and 3Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine; 4Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan, 5Department of Hygiene, Fujita Health University School of Medicine, Toyoake, Japan; 6Department of Nursing, School of Health Sciences, Faculty of Medicine, Niigata University, Niigata, Japan; 7Kyoto University Center for Student Health; 8Division of Epidemiology, Miyagi Prefectural Cancer Center, Natori, Japan and 9Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan
- Requests for reprints:
Koji Suzuki, Department of Public Health, Fujita Health University School of Helath Sciences, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan. Phone: 81-562-93-2537. E-mail: ksuzuki{at}fujita-hu.ac.jp
Abstract
Chronic inflammation contributes to the process of carcinogenesis, but few epidemiologic studies have examined associations with risk of lung cancer. Relationships between lung cancer risk and serum levels of both heat shock protein 70 (Hsp70) and high-sensitivity C-reactive protein (hsCRP) were investigated in a case-control study nested in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Serum samples and lifestyle information were collected at baseline from 39,242 men and women between 1988 and 1990. Of these, 240 deaths from lung cancer were identified through 1999, and 569 controls were matched for sex, age, and study area. Serum levels were measured in 189 cases and 377 controls for Hsp70 and in 209 cases and 425 controls for hsCRP. Odds ratios (95% confidence intervals) across quartiles, adjusted for confounding factors, including smoking habits, were 0.83 (0.44-1.58), 1.41 (0.77-2.60), and 1.84 (0.92-3.71) for Hsp70 (Ptrend = 0.042) and 1.13 (0.67-1.91), 0.66 (0.38-1.16), and 1.19 (0.70-2.02) for hsCRP (Ptrend = 0.941). In males, odds ratios (95% confidence intervals) across quartiles were 1.30 (0.59-2.84), 1.74 (0.83-3.67), and 2.49 (1.06-5.85) for Hsp70 (Ptrend = 0.029). High levels of serum Hsp70 might thus be associated with increased risk of lung cancer among Japanese males, although further studies are needed to clarify associations between chronic inflammation and lung cancer. (Cancer Epidemiol Biomarkers Prev 2006;15(9):1733–7)
- lung neoplasms
- heat shock protein 70
- inflammation
- nested case-control study
- reactive protein
- lung cancer
Footnotes
-
Grant support: Ministry of Education, Culture, Sports, Science and Technology of Japan Grant-in-Aid for Scientific Research on Priority Areas (C) (2) 12218216; Grant-in-Aid for Young Scientists (B) 16790329; and Grants-in-Aid for Scientific Research 61010076, 62010074, 63010074, 1010068, 2151065, 3151064, 4151063, 5151069, 6279102, 11181101, and 17015022 (JACC Study).
-
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
-
- Accepted July 5, 2006.
- Received January 4, 2006.
- Revision received May 17, 2006.
