Leanness, Smoking, and Enhanced Oxidative DNA Damage
- 1Department of Preventive Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; 2Department of Occupational Oncology, Institute of Industrial Ecological Sciences; and 3Department of Urology, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan
- Requests for reprints:
Tetsuya Mizoue, Department of Preventive Medicine, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashiku, 812-8582 Fukuoka, Japan. Phone: 81-92-642-6111; Fax: 81-92-642-6115. E-mail: mizoue{at}phealth.med.kyushu-u.ac.jp
Abstract
An increased risk of some forms of cancer, including lung cancer, among lean individuals has been consistent; however, there is a paucity of biological evidence supporting this relation. Subjects analyzed were 177 healthy Japanese workers who participated in a lifestyle intervention study. The levels of urinary 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative DNA damage, were measured using an automated high-pressure liquid chromatography and urinary creatinine levels were adjusted for before statistical analysis. A clear inverse association was found between body mass index (BMI) and 8-OHdG levels among smokers [Pearson correlation coefficient (r) = −0.48], and the association did not materially change after adjustment for potential confounding factors. In contrast, no apparent relation was observed between BMI and 8-OHdG levels among nonsmokers (r = −0.12), although lean nonsmokers had a slightly higher mean of 8-OHdG levels compared with nonlean nonsmokers. The interaction of smoking and BMI reached statistical significance (P = 0.04). Leanness may enhance oxidative DNA damage induced by smoking and thus serve as a marker of host susceptibility to smoking-related cancers. (Cancer Epidemiol Biomarkers Prev 2006;15(3):582–5)
Footnotes
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Grant support: The Third Term Comprehensive 10-Year Strategy for Cancer Control from the Ministry of Health, Labour and Welfare, Japan.
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The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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- Accepted January 10, 2006.
- Received August 30, 2005.
- Revision received December 12, 2005.
