Table of Contents

Cancer Prevention: The Importance of Accurate Risk Assessment

• Powel H. Brown and
• Asma Rashid

Genetic Association Studies: Time for a New Paradigm?

• Alice S. Whittemore

Note from the Editors

Publication Environment and Broad Investigation of the Genome

• Sholom Wacholder

The Reliable Identification of Disease-Gene Associations

• Paul D.P. Pharoah,
• Alison M. Dunning,
• Bruce A.J. Ponder,
• and Douglas F. Easton

Publication Policy or Publication Bias?

• Graham Byrnes,
• Lyle Gurrin,
• James Dowty,
• and John L. Hopper

Reflections on Publication Criteria for Genetic Association Studies

• Colin B. Begg

Diet and Cancer: The Disconnect Between Epidemiology and Randomized Clinical Trials

• Frank L. Meyskens, Jr. and
• Eva Szabo

Smoking Topography, Brand Switching, and Nicotine Delivery: Results from an In vivo Study

• David Hammond,
• Geoffrey T. Fong,
• K. Michael Cummings,
• and Andrew Hyland

Carcinogen Exposure during Short-term Switching from Regular to “Light” Cigarettes

• Neal L. Benowitz,
• Peyton Jacob III,
• John T. Bernert,
• Margaret Wilson,
• Langing Wang,
• Faith Allen,
• and Delia Dempsey

Catechol-O-Methyl-Transferase Functional Polymorphism and Nicotine Dependence: an Evaluation of Nonreplicated Results

• David T. Redden,
• Peter G. Shields,
• Leonard Epstein,
• E. Paul Wileyto,
• Stanislav O. Zakharkin,
• David B. Allison,
• and Caryn Lerman

Family History of Cancer, Its Combination with Smoking and Drinking, and Risk of Squamous Cell Carcinoma of the Esophagus

• Werner Garavello,
• Eva Negri,
• Renato Talamini,
• Fabio Levi,
• Paola Zambon,
• Luigino Dal Maso,
• Cristina Bosetti,
• Silvia Franceschi,
• and Carlo La Vecchia

Variation in Plasma Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3: Genetic Factors

• Libby M. Morimoto,
• Polly A. Newcomb,
• Emily White,
• Jeannette Bigler,
• and John D. Potter

Associations between Plasma Insulin-Like Growth Factor Proteins and C-Peptide and Quality of Life in Patients with Metastatic Colorectal Cancer

• Jeffrey A. Meyerhardt,
• Jeffrey A. Sloan,
• Daniel J. Sargent,
• Richard M. Goldberg,
• Michael Pollak,
• Roscoe F. Morton,
• Ramesh K. Ramanathan,
• Stephen K. Williamson,
• Brian P. Findlay,
• and Charles S. Fuchs

Associations among Circulating Sex Hormones, Insulin-Like Growth Factor, Lipids, and Mammographic Density in Postmenopausal Women

• Erin J. Aiello,
• Shelley S. Tworoger,
• Yutaka Yasui,
• Frank Z. Stanczyk,
• John Potter,
• Cornelia M. Ulrich,
• Melinda Irwin,
• and Anne McTiernan

α-Methylacyl-CoA Racemase Protein Expression Is Associated with the Degree of Differentiation in Breast Cancer Using Quantitative Image Analysis

• Agnieszka K. Witkiewicz,
• Sooryanarayana Varambally,
• Ronglai Shen,
• Rohit Mehra,
• Michael S. Sabel,
• Debashis Ghosh,
• Arul M. Chinnaiyan,
• Mark A. Rubin,
• and Celina G. Kleer

Decreased α-Methylacyl CoA Racemase Expression in Localized Prostate Cancer is Associated with an Increased Rate of Biochemical Recurrence and Cancer-Specific Death

• Mark A. Rubin,
• Tarek A. Bismar,
• Ove Andrén,
• Lorelei Mucci,
• Robert Kim,
• Ronglai Shen,
• Debashis Ghosh,
• John T. Wei,
• Arul M. Chinnaiyan,
• Hans-Olov Adami,
• Philip W. Kantoff,
• and Jan-Erik Johansson

Fruit and Vegetable Intake during Pregnancy and Risk for Development of Sporadic Retinoblastoma

• Manuela A. Orjuela,
• Lina Titievsky,
• Xinhua Liu,
• Marco Ramirez-Ortiz,
• Veronica Ponce-Castaneda,
• Evelia Lecona,
• Evelyn Molina,
• Katherine Beaverson,
• David H. Abramson,
• and Nancy E. Mueller

Neighborhood Socioeconomic Status and Hodgkin's Lymphoma Incidence in California

• Christina A. Clarke,
• Sally L. Glaser,
• Theresa H.M. Keegan,
• and Antoinette Stroup

Markers of Past Infection with Simian Virus 40 (SV40) and Risk of Incident Non-Hodgkin Lymphoma in a Maryland Cohort

• Dana E. Rollison,
• Kathy J. Helzlsouer,
• Neal A. Halsey,
• Keerti V. Shah,
• and Raphael P. Viscidi

Project PREVENT: A Randomized Trial to Reduce Multiple Behavioral Risk Factors for Colon Cancer

• Karen M. Emmons,
• Colleen M. McBride,
• Elaine Puleo,
• Kathryn I. Pollak,
• Elizabeth Clipp,
• Karen Kuntz,
• Bess H. Marcus,
• Melissa Napolitano,
• Jane Onken,
• Frank Farraye,
• and Robert Fletcher

Evidence for an Association between Compound Heterozygosity for Germ Line Mutations in the Hemochromatosis (HFE) Gene and Increased Risk of Colorectal Cancer

• James P. Robinson,
• Victoria L. Johnson,
• Pauline A. Rogers,
• Richard S. Houlston,
• Earmonn R. Maher,
• D.Timothy Bishop,
• D.Gareth R. Evans,
• Huw J.W. Thomas,
• Ian P.M. Tomlinson,
• and Andrew R.J. Silver

Intestinal Helminthiasis in Colombian Children Promotes a Th2 Response to Helicobacter pylori: Possible Implications for Gastric Carcinogenesis

• Mark T. Whary,
• Nataliya Sundina,
• Luis E. Bravo,
• Pelayo Correa,
• Francisco Quinones,
• Fanny Caro,
• and James G. Fox

5,10-Methylenetetrahydrofolate Reductase Polymorphisms and the Risk of Pancreatic Cancer

• Donghui Li,
• Maha Ahmed,
• Yanan Li,
• Li Jiao,
• Ta-Hsu Chou,
• Robert A. Wolff,
• Renato Lenzi,
• Douglas B. Evans,
• Melissa L. Bondy,
• Peter W. Pisters,
• James L. Abbruzzese,
• and Manal M. Hassan

Sex Differences in Risk of Lung Cancer Associated with Methylene-tetrahydrofolate Reductase Polymorphisms

• Qiuling Shi,
• Zhendong Zhang,
• Guojun Li,
• Patricia C. Pillow,
• Ladia M. Hernandez,
• Margaret R. Spitz,
• and Qingyi Wei

Behavioral Consequences of Testing for Obesity Risk

• Dominick L. Frosch,
• Paul Mello,
• and Caryn Lerman

Physical Activity and the Risk of Prostate Cancer in The Netherlands Cohort Study, Results after 9.3 Years of Follow-up

• Maurice P.A. Zeegers,
• Miranda J.M. Dirx,
• and Piet A. van den Brandt

Energy Balance and Breast Cancer Risk

• Alecia Malin,
• Charles E. Matthews,
• Xiao-Ou Shu,
• Hui Cai,
• Qi Dai,
• Fan Jin,
• Yu-Tang Gao,
• and Wei Zheng

Prenatal and Perinatal Correlates of Adult Mammographic Breast Density

• James R. Cerhan,
• Thomas A. Sellers,
• Carol A. Janney,
• V. Shane Pankratz,
• Kathy R. Brandt,
• and Celine M. Vachon

Menstrual Cycle Characteristics and Incidence of Premenopausal Breast Cancer

• Kathryn L. Terry,
• Walter C. Willett,
• Janet W. Rich-Edwards,
• David J. Hunter,
• and Karin B. Michels

Pregnancy Hormone Concentrations Across Ethnic Groups: Implications for Later Cancer Risk

• Nancy Potischman,
• Rebecca Troisi,
• Ravi Thadhani,
• Robert N. Hoover,
• Kevin Dodd,
• William W. Davis,
• Patrick M. Sluss,
• Chung-Cheng Hsieh,
• and Rachel Ballard-Barbash

Association of Genetic Polymorphisms with Serum Estrogens Measured Multiple Times During a 2-Year Period in Premenopausal Women

• Galina Lurie,
• Gertraud Maskarinec,
• Rudolf Kaaks,
• Frank Z. Stanczyk,
• and Loïc Le Marchand

Acquisition and Persistence of Human Papillomavirus Infection in Younger Men: A Prospective Follow-up Study among Danish Soldiers

• Susanne Krüger Kjaer,
• Christian Munk,
• Jeanette Falck Winther,
• Hans Ole Jørgensen,
• Chris J.L.M. Meijer,
• and Adriaan J.C. van den Brule

A Comparison of Bilateral Breast Cancers in BRCA Carriers

• Jeffrey N. Weitzel,
• Mark Robson,
• Barbara Pasini,
• Siranoush Manoukian,
• Dominique Stoppa-Lyonnet,
• Henry T. Lynch,
• Jane McLennan,
• William D. Foulkes,
• Teresa Wagner,
• Nadine Tung,
• Parviz Ghadirian,
• Olufunmilayo Olopade,
• Claudine Isaacs,
• Charmaine Kim-Sing,
• Pal Møller,
• Susan L. Neuhausen,
• Kelly Metcalfe,
• Ping Sun,
• and Steven A. Narod

Genetic Variation in XPD, Sun Exposure, and Risk of Skin Cancer

• Jiali Han,
• Graham A. Colditz,
• Jun S. Liu,
• and David J. Hunter

Examining Population Stratification via Individual Ancestry Estimates versus Self-Reported Race

• Jill S. Barnholtz-Sloan,
• Ranajit Chakraborty,
• Thomas A. Sellers,
• and Ann G. Schwartz

Is the Association with Fiber from Foods in Colorectal Cancer Confounded by Folate Intake?

• Sheila A. Bingham,
• Teresa Norat,
• Aurelie Moskal,
• Pietro Ferrari,
• Nadia Slimani,
• Françoise Clavel-Chapelon,
• Emmanuelle Kesse,
• Alexandra Nieters,
• Heiner Boeing,
• Anne Tjønneland,
• Kim Overvad,
• Carmen Martinez,
• Miren Dorronsoro,
• Carlos A. González,
• Eva Ardanaz,
• Carmen Navarro,
• José R. Quirós,
• Timothy J. Key,
• Nicholas E. Day,
• Antonia Trichopoulou,
• Androniki Naska,
• Vittorio Krogh,
• Rosario Tumino,
• Domenico Palli,
• Salvatore Panico,
• Paolo Vineis,
• H.B. Bueno-de-Mesquita,
• Marga C. Ocké,
• Petra H.M. Peeters,
• Göran Berglund,
• Göran Hallmans,
• Eiliv Lund,
• Guri Skeie,
• Rudolf Kaaks,
• and Elio Riboli

Prediagnostic Plasma Vascular Endothelial Growth Factor Levels and Risk of Prostate Cancer

• Haojie Li,
• Philip W. Kantoff,
• Jing Ma,
• Meir J. Stampfer,
• and Daniel J. George

Dietary Intake of Folate and Riboflavin, MTHFR C677T Genotype, and Colorectal Adenoma Risk: A Dutch Case-Control Study

• Maureen van den Donk,
• Brian Buijsse,
• Saskia W. van den Berg,
• Marga C. Ocké,
• Jan L. Harryvan,
• Fokko M. Nagengast,
• Frans J. Kok,
• and Ellen Kampman

Genetic Polymorphisms of the Transforming Growth Factor-β1 Gene and Breast Cancer Risk: A Possible Dual Role at Different Cancer Stages

• Aesun Shin,
• Xiao-Ou Shu,
• Qiuyin Cai,
• Yu-Tang Gao,
• and Wei Zheng

Lack of Association of Physical Activity and Obesity with Incident Pancreatic Cancer in Elderly Women

• Penny J. Sinner,
• Kathryn H. Schmitz,
• Kristin E. Anderson,
• and Aaron R. Folsom

No Association Between Dietary Glycemic Index or Load and Pancreatic Cancer Incidence in Postmenopausal Women

• Kimberly J. Johnson,
• Kristin E. Anderson,
• Lisa Harnack,
• Ching-Ping Hong,
• and Aaron R. Folsom

Common Leptin Receptor Polymorphisms do not Modify the Effect of Alcohol Ingestion on Serum Leptin Levels in a Controlled Feeding and Alcohol Ingestion Study

• Mark J. Roth,
• Dina N. Paltoo,
• Paul S. Albert,
• David J. Baer,
• Joseph T. Judd,
• Joseph Tangrea,
• and Philip R. Taylor

Subsite-Specific Colorectal Cancer in Diabetic and Nondiabetic Patients

• E. Lim,
• I.T. Jones,
• P. Gibbs,
• S. McLaughlan,
• I. Faragher,
• I. Skinner,
• M.W. Chao,
• and J. Johns

Robustness of Case-Control Studies to Population Stratification

• Gary A. Heiman,
• Prakash Gorroochurn,
• Susan E. Hodge,
• and David A. Greenberg

Accuracy and Reproducibility of Short Tandem Repeat Assays

• Jeannette Bigler

Soluble Epidermal Growth Factor Receptor (sEGFR) and Cancer Antigen 125 (CA 125) as Screening and Diagnostic Tests for Epithelial Ovarian Cancer