This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Enroth, H. Articles by Rohan, T. Search for Related Content PubMed PubMed Citation Articles by Enroth, H. Articles by Rohan, T.

Helicobacter pylori Strain Types and Risk of Gastric Cancer: A Case-Control Study¹

Department of Medical Epidemiology, Karolinska Institute, 17177 Stockholm, Sweden [H. E., L. E., O. N.]; Department of Pathology, University Hospital, 75185 Uppsala, Sweden [W. K.]; Swedish Institute for Infectious Disease Control, 17182 Solna, Sweden [L. E.]; and Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, New York 10461 [T. R.]

The aim of this novel endoscopy clinic-based case-control study was to explore the influence of different Helicobacter pylori strain types on the risk of gastric adenocarcinoma using isolated bacterial strains, tissue samples, and sera. We included 72 cases with gastric adenocarcinoma and 324 age- and sex-matched controls. Histological characterization, culture, molecular typing of H. pylori genes by PCR (cagA/vacA), conventional IgG ELISA, and immunoblotting (Western blot) for the CagA and VacA proteins were performed. With four tests combined, H. pylori infection was detected in 57 (79%) cases and 213 (66%) controls. A positive association between H. pylori infection and gastric cancer risk was found [odds ratio (OR), 2.1; 95% confidence interval, 1.1–3.9]. Type I (OR, 1.8), intermediate (OR, 2.0), and type II (OR, 0.2) strains of H. pylori presented different serum antibody levels and different levels of association with gastric cancer. Our case-control study, based on molecular characterization and serology, provides further evidence that infection by more virulent strains of H. pylori and the presence of antibodies toward the CagA protein can be used as markers for an increased risk of gastric adenocarcinoma and that the strain types of H. pylori could be used in the future to determine disease outcome.

This article has been cited by other articles:

				G. Ayala, J. Torres-Mena, and L. Lopez-Carrillo Association between Helicobacter pylori VacA antigens and gastric cancer depends on the detection method used: immunoblot versus neutralization of the vacuolating activity of VacA J. Med. Microbiol., January 1, 2008; 57(1): 9 - 14. [Abstract] [Full Text] [PDF]

				A. Skoglund, B. Bjorkholm, C. Nilsson, A. F. Andersson, C. Jernberg, K. Schirwitz, C. Enroth, M. Krabbe, and L. Engstrand Functional Analysis of the M.HpyAIV DNA Methyltransferase of Helicobacter pylori J. Bacteriol., December 15, 2007; 189(24): 8914 - 8921. [Abstract] [Full Text] [PDF]

				J. D. Oh, H. Kling-Backhed, M. Giannakis, J. Xu, R. S. Fulton, L. A. Fulton, H. S. Cordum, C. Wang, G. Elliott, J. Edwards, et al. The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: Evolution during disease progression PNAS, June 27, 2006; 103(26): 9999 - 10004. [Abstract] [Full Text] [PDF]

				D. Schottenfeld and J. Beebe-Dimmer Chronic inflammation: a common and important factor in the pathogenesis of neoplasia. CA Cancer J Clin, March 1, 2006; 56(2): 69 - 83. [Abstract] [Full Text] [PDF]

				C. Nilsson, A. Sillen, L. Eriksson, M.-L. Strand, H. Enroth, S. Normark, P. Falk, and L. Engstrand Correlation between cag Pathogenicity Island Composition and Helicobacter pylori-Associated Gastroduodenal Disease Infect. Immun., November 1, 2003; 71(11): 6573 - 6581. [Abstract] [Full Text] [PDF]

				B. M. Bjorkholm, J. L. Guruge, J. D. Oh, A. J. Syder, N. Salama, K. Guillemin, S. Falkow, C. Nilsson, P. G. Falk, L. Engstrand, et al. Colonization of Germ-free Transgenic Mice with Genotyped Helicobacter pylori Strains from a Case-Control Study of Gastric Cancer Reveals a Correlation between Host Responses and HsdS Components of Type I Restriction-Modification Systems J. Biol. Chem., September 6, 2002; 277(37): 34191 - 34197. [Abstract] [Full Text] [PDF]

				B. Bjorkholm, A. Lundin, A. Sillen, K. Guillemin, N. Salama, C. Rubio, J. I. Gordon, P. Falk, and L. Engstrand Comparison of Genetic Divergence and Fitness between Two Subclones of Helicobacter pylori Infect. Immun., December 1, 2001; 69(12): 7832 - 7838. [Abstract] [Full Text] [PDF]