| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Epidemiology Research Group [J. B., B. B., G. C., E. M., S. B.] and Breast Center [J. R.], Saint-Sacrement Hospital CHA; Department of Social and Preventive Medicine, Laval University [J. B., E. M.]; and Clinique Radiologique Audet [G. C.], Quebec City, Quebec, G1S 4L8 Canada
The extent of breast tissue density on mammograms is one of the strongest risk factors for breast cancer. The aim of this analysis was to evaluate whether tamoxifen can affect mammographic breast density. Subjects were participants in the National Surgical Adjuvant Breast Project Breast Cancer Prevention Trial (BCPT), recruited and followed at the Breast Center of Saint-Sacrement Hospital in Quebec City, Canada. The Breast Cancer Prevention Trial is a double-blind trial in which women at high risk of breast cancer were randomized to receive either 20 mg tamoxifen per day or placebo. Mammograms were taken before treatment began and yearly thereafter. For the purpose of this analysis, Wolfe’s parenchymal pattern and the percentage of the breast showing tissue densities were assessed by review of pre- and posttreatment mammograms without knowledge of treatment assignment. Among the 69 women included in this analysis, 36 received tamoxifen and 33 received placebo for an average of 3.3 and 3.5 years, respectively. Among women receiving tamoxifen, 16 of 36 (44.4%) changed to a parenchymal pattern of lower density compared with 5 of 33 (15.2%) women receiving placebo (P = 0.010). Moreover, in the tamoxifen-treated group, the difference in the percentage of the breast showing tissue densities between the pre- and posttreatment mammograms reached -9.4% on average compared with a reduction of -3.6% in the placebo group (P = 0.010). Our data show that tamoxifen can reduce high-risk mammographic features. Breast densities should be evaluated as possible early markers of the preventive effect of selective estrogen receptor modulators.
This article has been cited by other articles:
|
|
 |
|
  J. Eng-Wong, J. Orzano-Birgani, C. K. Chow, D. Venzon, J. Yao, C. E. Galbo, J. A. Zujewski, and S. Prindiville Effect of Raloxifene on Mammographic Density and Breast Magnetic Resonance Imaging in Premenopausal Women at Increased Risk for Breast Cancer Cancer Epidemiol. Biomarkers Prev., July 1, 2008; 17(7): 1696 - 1701. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Berube, C. Diorio, and J. Brisson Multivitamin-multimineral supplement use and mammographic breast density Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1400 - 1404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Kelemen, V. S. Pankratz, T. A. Sellers, K. R. Brandt, A. Wang, C. Janney, Z. S. Fredericksen, J. R. Cerhan, and C. M. Vachon Age-specific Trends in Mammographic Density: The Minnesota Breast Cancer Family Study Am. J. Epidemiol., May 1, 2008; 167(9): 1027 - 1036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Hwang, D. L. Miglioretti, R. Ballard-Barbash, D. L. Weaver, K. Kerlikowske, and for the National Cancer Institute Breast Cancer Su Association between Breast Density and Subsequent Breast Cancer Following Treatment for Ductal Carcinoma In situ Cancer Epidemiol. Biomarkers Prev., December 1, 2007; 16(12): 2587 - 2593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Tamimi, C. Byrne, G. A. Colditz, and S. E. Hankinson Endogenous Hormone Levels, Mammographic Density, and Subsequent Risk of Breast Cancer in Postmenopausal Women J Natl Cancer Inst, August 1, 2007; 99(15): 1178 - 1187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Vachon, K. R. Brandt, K. Ghosh, C. G. Scott, S. D. Maloney, M. J. Carston, V. S. Pankratz, and T. A. Sellers Mammographic Breast Density as a General Marker of Breast Cancer Risk Cancer Epidemiol. Biomarkers Prev., January 1, 2007; 16(1): 43 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Fabian and B. F. Kimler Mammographic Density: Use in Risk Assessment and as a Biomarker in Prevention Trials J. Nutr., October 1, 2006; 136(10): 2705S - 2708S. [Full Text] [PDF]
|
|
|
|
|
|
R. Warren, J. Skinner, E. Sala, E. Denton, M. Dowsett, E. Folkerd, C. S. Healey, A. Dunning, D. Doody, B. Ponder, et al. Associations among Mammographic Density, Circulating Sex Hormones, and Polymorphisms in Sex Hormone Metabolism Genes in Postmenopausal Women. Cancer Epidemiol. Biomarkers Prev., August 1, 2006; 15(8): 1502 - 1508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Palomares, J. R.B. Machia, C. D. Lehman, J. R. Daling, and A. McTiernan Mammographic density correlation with gail model breast cancer risk estimates and component risk factors. Cancer Epidemiol. Biomarkers Prev., July 1, 2006; 15(7): 1324 - 1330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Tamimi, S. E. Hankinson, G. A. Colditz, and C. Byrne Endogenous Sex Hormone Levels and Mammographic Density among Postmenopausal Women Cancer Epidemiol. Biomarkers Prev., November 1, 2005; 14(11): 2641 - 2647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Stuedal, I. T. Gram, Y. Bremnes, H. Adlercreutz, M. B. Veierod, and G. Ursin Plasma Levels of Enterolactone and Percentage Mammographic Density among Postmenopausal Women Cancer Epidemiol. Biomarkers Prev., September 1, 2005; 14(9): 2154 - 2159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Berube, C. Diorio, B. Masse, N. Hebert-Croteau, C. Byrne, G. Cote, M. Pollak, M. Yaffe, and J. Brisson Vitamin D and Calcium Intakes from Food or Supplements and Mammographic Breast Density Cancer Epidemiol. Biomarkers Prev., July 1, 2005; 14(7): 1653 - 1659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Cerhan, T. A. Sellers, C. A. Janney, V. S. Pankratz, K. R. Brandt, and C. M. Vachon Prenatal and Perinatal Correlates of Adult Mammographic Breast Density Cancer Epidemiol. Biomarkers Prev., June 1, 2005; 14(6): 1502 - 1508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. W. Brawley and B. S. Kramer Cancer Screening in Theory and in Practice J. Clin. Oncol., January 10, 2005; 23(2): 293 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ziv, J. Tice, R. Smith-Bindman, J. Shepherd, S. Cummings, and K. Kerlikowske Mammographic Density and Estrogen Receptor Status of Breast Cancer Cancer Epidemiol. Biomarkers Prev., December 1, 2004; 13(12): 2090 - 2095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Maskarinec, Y. Takata, A. A. Franke, A. E. Williams, and S. P. Murphy A 2-Year Soy Intervention in Premenopausal Women Does Not Change Mammographic Densities J. Nutr., November 1, 2004; 134(11): 3089 - 3094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Habel, J. J. Dignam, S. R. Land, M. Salane, A. M. Capra, and T. B. Julian Mammographic Density and Breast Cancer After Ductal Carcinoma In Situ J Natl Cancer Inst, October 6, 2004; 96(19): 1467 - 1472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Berube, C. Diorio, W. Verhoek-Oftedahl, and J. Brisson Vitamin D, Calcium, and Mammographic Breast Densities Cancer Epidemiol. Biomarkers Prev., September 1, 2004; 13(9): 1466 - 1472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Ursin, S. L. Palla, B. A. Reboussin, S. Slone, C. Wasilauskas, M. C. Pike, and G. A. Greendale Post-Treatment Change in Serum Estrone Predicts Mammographic Percent Density Changes in Women Who Received Combination Estrogen and Progestin in the Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial J. Clin. Oncol., July 15, 2004; 22(14): 2842 - 2848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Frankenfeld, A. McTiernan, E. J. Aiello, W. K. Thomas, K. LaCroix, J. Schramm, S. M. Schwartz, V. L. Holt, and J. W. Lampe Mammographic Density in Relation to Daidzein-Metabolizing Phenotypes in Overweight, Postmenopausal Women Cancer Epidemiol. Biomarkers Prev., July 1, 2004; 13(7): 1156 - 1162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Harvey and V. E. Bovbjerg Quantitative Assessment of Mammographic Breast Density: Relationship with Breast Cancer Risk Radiology, January 1, 2004; 230(1): 29 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Brisson, C. Diorio, and B. Masse Wolfe's Parenchymal Pattern and Percentage of the Breast with Mammographic Densities: Redundant or Complementary Classifications? Cancer Epidemiol. Biomarkers Prev., August 1, 2003; 12(8): 728 - 732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Stone, A. Gunasekara, L. J. Martin, M. Yaffe, S. Minkin, and N. F. Boyd The Detection of Change in Mammographic Density Cancer Epidemiol. Biomarkers Prev., July 1, 2003; 12(7): 625 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. H. Gann and M. Morrow Combined Hormone Therapy and Breast Cancer: A Single-Edged Sword JAMA, June 25, 2003; 289(24): 3304 - 3306. [Full Text] [PDF]
|
|
|
|
|
|
R. T. Chlebowski and A. McTiernan Biological Significance of Interventions That Change Breast Density J Natl Cancer Inst, January 1, 2003; 95(1): 4 - 5. [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Fabian, B. F. Kimler, D. A. Brady, M. S. Mayo, C. H. J. Chang, J. A. Ferraro, C. M. Zalles, A. L. Stanton, S. Masood, W. E. Grizzle, et al. A Phase II Breast Cancer Chemoprevention Trial of Oral {alpha}-Difluoromethylornithine: Breast Tissue, Imaging, and Serum and Urine Biomarkers Clin. Cancer Res., October 1, 2002; 8(10): 3105 - 3117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Messina, C. Gardner, and S. Barnes Gaining Insight into the Health Effects of Soy but a Long Way Still to Go: Commentary on the Fourth International Symposium on the Role of Soy in Preventing and Treating Chronic Disease J. Nutr., March 1, 2002; 132(3): 547S - 551. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
