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Cancer Research Center, University of Hawaii, Honolulu, Hawaii 96813 [L. N. K., J. H. H., L. R. W.]; Stanford University, Stanford, California 94305 [A. S. W., R. S. P., Jr.]; University of Southern California, Los Angeles, California 90333 [A. H. W.]; British Columbia Cancer Agency, Vancouver, British Columbia, 15Z 4E6 Canada [R. P. G.]; Northern California Cancer Center, Union City, California 94587 [E. M. J., D. W. W.]; Columbia University, New York, New York [G. R. H.]; Lawrence Berkeley Laboratory, University of California, Berkeley, California 94720 [D. M. D.]
The evidence for a protective effect of vegetables, fruits, and legumes against prostate cancer is weak and inconsistent. We examined the relationship of these food groups and their constituent foods to prostate cancer risk in a multicenter case-control study of African-American, white, Japanese, and Chinese men. Cases (n = 1619) with histologically confirmed prostate cancer were identified through the population-based tumor registries of Hawaii, San Francisco, and Los Angeles in the United States and British Columbia and Ontario in Canada. Controls (n = 1618) were frequency-matched to cases on ethnicity, age, and region of residence of the case, in a ratio of approximately 1:1. Dietary and other information was collected by in-person home interview; a blood sample was obtained from control subjects for prostate-specific antigen determination. Odds ratios (OR) were estimated using logistic regression, adjusting for age, geographic location, education, calories, and when indicated, ethnicity. Intake of legumes (whether total legumes, soyfoods specifically, or other legumes) was inversely related to prostate cancer (OR for highest relative to lowest quintile for total legumes = 0.62; P for trend = 0.0002); results were similar when restricted to prostate-specific antigen-normal controls or to advanced cases. Intakes of yellow-orange and cruciferous vegetables were also inversely related to prostate cancer, especially for advanced cases, among whom the highest quintile OR for yellow-orange vegetables = 0.67 (P for trend = 0.01) and the highest quintile OR for cruciferous vegetables = 0.61 (P for trend = 0.006). Intake of tomatoes and of fruits was not related to risk. Findings were generally consistent across ethnic groups. These results suggest that legumes (not limited to soy products) and certain categories of vegetables may protect against prostate cancer.
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S. K. Srivastava, D. Xiao, K. L. Lew, P. Hershberger, D. M. Kokkinakis, C. S. Johnson, D. L. Trump, and S. V. Singh Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo Carcinogenesis, October 1, 2003; 24(10): 1665 - 1670. [Abstract] [Full Text] [PDF]
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D. Xiao, S. K. Srivastava, K. L. Lew, Y. Zeng, P. Hershberger, C. S. Johnson, D. L. Trump, and S. V. Singh Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis Carcinogenesis, May 1, 2003; 24(5): 891 - 897. [Abstract] [Full Text] [PDF]
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A. W. Hsing, A. P. Chokkalingam, Y.-T. Gao, M. P. Madigan, J. Deng, G. Gridley, and J. F. Fraumeni Jr. Allium Vegetables and Risk of Prostate Cancer: A Population-Based Study J Natl Cancer Inst, November 6, 2002; 94(21): 1648 - 1651. [Abstract] [Full Text] [PDF]
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E. Giovannucci A Review of Epidemiologic Studies of Tomatoes, Lycopene, and Prostate Cancer Experimental Biology and Medicine, November 1, 2002; 227(10): 852 - 859. [Abstract] [Full Text] [PDF]
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C. W. Hadley, E. C. Miller, S. J. Schwartz, and S. K. Clinton Tomatoes, Lycopene, and Prostate Cancer: Progress and Promise Experimental Biology and Medicine, November 1, 2002; 227(10): 869 - 880. [Abstract] [Full Text] [PDF]
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J. D. Brooks, M. F. Goldberg, L. A. Nelson, D. Wu, and W. G. Nelson Identification of Potential Prostate Cancer Preventive Agents through Induction of Quinone Reductase in Vitro Cancer Epidemiol. Biomarkers Prev., September 1, 2002; 11(9): 868 - 875. [Abstract] [Full Text] [PDF]
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A. R. Kristal Diet and Trend in Prostate-Specific Antigen: Inferences for Prostate Cancer Risk J. Clin. Oncol., September 1, 2002; 20(17): 3570 - 3571. [Full Text] [PDF]
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D. Xiao and S. V. Singh Phenethyl Isothiocyanate-induced Apoptosis in p53-deficient PC-3 Human Prostate Cancer Cell Line Is Mediated by Extracellular Signal-regulated Kinases Cancer Res., July 1, 2002; 62(13): 3615 - 3619. [Abstract] [Full Text] [PDF]
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 T. M. Vogt, S. T. Mayne, B. I. Graubard, C. A. Swanson, A. L. Sowell, J. B. Schoenberg, G. M. Swanson, R. S. Greenberg, R. N. Hoover, R. B. Hayes, et al. Serum Lycopene, Other Serum Carotenoids, and Risk of Prostate Cancer in US Blacks and Whites Am. J. Epidemiol., June 1, 2002; 155(11): 1023 - 1032. [Abstract] [Full Text] [PDF]
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E. Giovannucci, E. B. Rimm, Y. Liu, M. J. Stampfer, and W. C. Willett A Prospective Study of Tomato Products, Lycopene, and Prostate Cancer Risk J Natl Cancer Inst, March 6, 2002; 94(5): 391 - 398. [Abstract] [Full Text] [PDF]
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P. Talalay and J. W. Fahey Phytochemicals from Cruciferous Plants Protect against Cancer by Modulating Carcinogen Metabolism J. Nutr., November 1, 2001; 131(11): 3027S - 3033. [Abstract] [Full Text] [PDF]
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L. H. Kushi, J. E. Cunningham, J. R. Hebert, R. H. Lerman, E. V. Bandera, and J. Teas The Macrobiotic Diet in Cancer J. Nutr., November 1, 2001; 131(11): 3056S - 3064. [Abstract] [Full Text] [PDF]
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J. D. Brooks, V. G. Paton, and G. Vidanes Potent Induction of Phase 2 Enzymes in Human Prostate Cells by Sulforaphane Cancer Epidemiol. Biomarkers Prev., September 1, 2001; 10(9): 949 - 954. [Abstract] [Full Text] [PDF]
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