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Lewis Antigen Alterations in a Population at High Risk of Stomach Cancer¹

Nuestra Señora de Aránzazu Hospital, University of the Basque Country, San Sebastián, Spain [J. T., J. G.]; International Agency for Research on Cancer, Lyon, France [M. P., N. M.]; and Cancer Control Center of the Tachira State, San Cristobal, Venezuela [J. V., G. L., S. P., E. C., W. O.]

Anomalous Lewis^a antigen and sulfomucin expression are considered as markers of progression in precursor lesions of gastric cancer. Additionally, Lewis antigen and secretor phenotype have been related to Helicobacter pylori infection and gastric epithelial damage. The two objectives of this study were to correlate Lewis antigen alterations with histochemical changes and to explore the relationship between Lewis and secretor phenotypes and gastric epithelial damage related to H. pylori infection. The study subjects were selected from a chemoprevention trial in Tachira State, Venezuela, an area with a high risk of gastric cancer.

Anomalous Lewis^a antigen expression in Lewis (a-b+) phenotype individuals was closely related to the severity of the histological lesions, especially to dysplasia and type III intestinal metaplasia lesions. A weak relationship was observed between nonsecretor individuals and more advanced lesions of IM, but this association was not statistically significant. There was no relationship between secretor phenotype and H. pylori status, atrophy, regenerative activity, erosion, or ulcer.

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