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Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, 00250 Helsinki, Finland [K. M., A. H.]; Unit of Cancer Epidemiology (INSERM U521), Gustave-Roussy Institute, 94805 Villejuif, France [N. J., S. B.]; Departments of Oncology [V. K.] and Surgery [M. E.], Kuopio University Hospital, 70211 Kuopio, Finland; Departments of Clinical Pathology and Forensic Medicine [V-M. K.] and Clinical Nutrition [M. U.], University of Kuopio, 70211 Kuopio, Finland; and International Agency for Research on Cancer, 69372 Lyon, France [H. V.]
The
potential role of the polymorphism in the CYP17 gene was
evaluated in a case-control study with 483 incident breast cancer
patients and 482 population controls, all of homogenous Finnish origin.
Our data disagree with the earlier suggestions that the minor
A2 variant of CYP17 would pose an
increased risk for developing advanced breast cancer. In contrast, a
tendency of inverse association was found for premenopausal women
carrying the A2 allele containing genotypes with a
multivariate adjusted odds ratio of 0.58 approaching statistical
significance (95% CI, 0.31–1.07). Agreeing with previous
observations, the protective effect of later age at menarche (
13
years) was mainly limited to women with A1/A1 genotype,
although this could only be seen in premenopausal women (odds ratio,
0.34; 95% CI, 0.15–0.76). Similarly, we found a remarkably lower risk
for premenopausal women with at least one child (odds ratio, 0.22; 95%
CI, 0.07–0.62) to be mainly attributable to the A1/A1
genotype. CYP17 genotypes may thus modify
individual breast cancer proneness in certain subpopulations, although
they appear not to have any major modifying role in the risk of this
malignancy overall. Because these findings are based on relatively
small numbers in stratified analysis, they should, however, be
interpreted with caution before being confirmed in future studies.
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