This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Aronson, K. J. Articles by Weber, J.-P. Search for Related Content PubMed PubMed Citation Articles by Aronson, K. J. Articles by Weber, J.-P.

Breast Adipose Tissue Concentrations of Polychlorinated Biphenyls and Other Organochlorines and Breast Cancer Risk¹

Departments of Community Health and Epidemiology [K. J. A., C. G. W.], Surgery [E. E. S.], and Pathology [S. K. S.], Queen’s University, Kingston, Ontario, K7L 3N6 Canada; Division of Clinical Epidemiology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany [A. B. M.]; Surgical Oncology, Princess Margaret Hospital, Toronto, Ontario, M5G 2M9 Canada [D. R. M.]; Departments of Surgery [L. A. L., E. B. F., G. Y. H., C. H., T. R.] and Pathology [W. M. H.], Women’s College Hospital, Toronto, Ontario, M5S 1B2 Canada; and Le Centre de Toxicologie du Québec, Sainte-Foy, Quebec, G1V 4G2 Canada [J-P. W.]

Numerous studies have examined the relationship between organochlorines and breast cancer, but the results are not consistent. In most studies, organochlorines were measured in serum, but levels in breast adipose tissue are higher and represent cumulative internal exposure at the target site for breast cancer. Therefore, a hospital-based case-control study was conducted in Ontario, Canada to evaluate the association between breast cancer risk and breast adipose tissue concentrations of several organochlorines. Women scheduled for excision biopsy of the breast were enrolled and completed a questionnaire. The biopsy tissue of 217 cases and 213 benign controls frequency matched by study site and age in 5-year groups was analyzed for 14 polychlorinated biphenyl (PCB) congeners, total PCBs, and 10 other organochlorines, including p,p'-1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene. Multiple logistic regression was used to assess the magnitude of risk. While adjusting for age, menopausal status, and other factors, odds ratios (ORs) were above 1.0 for almost all organochlorines except five pesticide residues. The ORs were above two in the highest concentration categories of PCB congeners 105 and 118, and the ORs for these PCBs increased linearly across categories (Ps for trend 0.01). Differences by menopausal status are noted especially for PCBs 105 and 118, with risks higher among premenopausal women, and for PCBs 170 and 180, with risks higher among postmenopausal women. Clear associations with breast cancer risk were demonstrated in this study for some PCBs measured in breast adipose tissue.

This article has been cited by other articles:

				D. Caserta, L. Maranghi, A. Mantovani, R. Marci, F. Maranghi, and M. Moscarini Impact of endocrine disruptor chemicals in gynaecology Hum. Reprod. Update, January 1, 2008; 14(1): 59 - 72. [Abstract] [Full Text] [PDF]

				P. G. Shields Understanding population and individual risk assessment: the case of polychlorinated biphenyls. Cancer Epidemiol. Biomarkers Prev., May 1, 2006; 15(5): 830 - 839. [Abstract] [Full Text] [PDF]

				J. A. Rusiecki, A. Matthews, S. Sturgeon, R. Sinha, E. Pellizzari, T. Zheng, and D. Baris A Correlation Study of Organochlorine Levels in Serum, Breast Adipose Tissue, and Gluteal Adipose Tissue among Breast Cancer Cases in India Cancer Epidemiol. Biomarkers Prev., May 1, 2005; 14(5): 1113 - 1124. [Abstract] [Full Text] [PDF]

				O. Raaschou-Nielsen, M. Pavuk, A. LeBlanc, P. Dumas, J. Philippe Weber, A. Olsen, A. Tjonneland, K. Overvad, and J. H. Olsen Adipose Organochlorine Concentrations and Risk of Breast Cancer Among Postmenopausal Danish Women Cancer Epidemiol. Biomarkers Prev., January 1, 2005; 14(1): 67 - 74. [Abstract] [Full Text] [PDF]

				M. Petreas, D. Smith, S. Hurley, S. S. Jeffrey, D. Gilliss, and P. Reynolds Distribution of Persistent, Lipid-Soluble Chemicals in Breast and Abdominal Adipose Tissues: Lessons Learned from a Breast Cancer Study Cancer Epidemiol. Biomarkers Prev., March 1, 2004; 13(3): 416 - 424. [Abstract] [Full Text]

				J. A. Fulop Integrative Tumor Board: Recurrent Breast Cancer or New Primary? Integr Cancer Ther, September 1, 2003; 2(3): 276 - 283. [PDF]

				R. J. Letcher, J. G. Lemmen, B. van der Burg, A. Brouwer, A. Bergman, J. P. Giesy, and M. van den Berg In Vitro Antiestrogenic Effects of Aryl Methyl Sulfone Metabolites of Polychlorinated Biphenyls and 2,2-Bis(4-chlorophenyl)-1,1-dichloroethene on 17{beta}-Estradiol-Induced Gene Expression in Several Bioassay Systems Toxicol. Sci., October 1, 2002; 69(2): 362 - 372. [Abstract] [Full Text] [PDF]

				E. E. Calle, H. Frumkin, S. J. Henley, D. A. Savitz, and M. J. Thun Organochlorines and Breast Cancer Risk CA Cancer J Clin, September 1, 2002; 52(5): 301 - 309. [Abstract] [Full Text] [PDF]

				M. D. Gammon, M. S. Wolff, A. I. Neugut, S. M. Eng, S. L. Teitelbaum, J. A. Britton, M. B. Terry, B. Levin, S. D. Stellman, G. C. Kabat, et al. Environmental Toxins and Breast Cancer on Long Island. II. Organochlorine Compound Levels in Blood Cancer Epidemiol. Biomarkers Prev., August 1, 2002; 11(8): 686 - 697. [Abstract] [Full Text] [PDF]

				P. L. Grover and F. L. Martin The initiation of breast and prostate cancer Carcinogenesis, July 1, 2002; 23(7): 1095 - 1102. [Abstract] [Full Text] [PDF]

				A. Demers, P. Ayotte, J. Brisson, S. Dodin, J. Robert, and E. Dewailly Plasma Concentrations of Polychlorinated Biphenyls and the Risk of Breast Cancer: A Congener-specific Analysis Am. J. Epidemiol., April 1, 2002; 155(7): 629 - 635. [Abstract] [Full Text] [PDF]

				F. Laden, G. Collman, K. Iwamoto, A. J. Alberg, G. S. Berkowitz, J. L. Freudenheim, S. E. Hankinson, K. J. Helzlsouer, T. R. Holford, H.-Y. Huang, et al. 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and Polychlorinated Biphenyls and Breast Cancer: Combined Analysis of Five U.S. Studies J Natl Cancer Inst, May 16, 2001; 93(10): 768 - 775. [Abstract] [Full Text] [PDF]

				O. M Faroon, S. Keith, D. Jones, and C. De Rosa Carcinogenic effects of polychlorinated biphenyls Toxicology and Industrial Health, March 1, 2001; 17(2): 41 - 62. [Abstract] [PDF]

				F. L. Martin Genotoxins and the initiation of sporadic breast cancer Mutagenesis, March 1, 2001; 16(2): 155 - 161. [Abstract] [Full Text] [PDF]

				E. M. Ward, P. Schulte, B. Grajewski, A. Andersen, D. G. Patterson Jr., W. Turner, E. Jellum, J. A. Deddens, J. Friedland, N. Roeleveld, et al. Serum Organochlorine Levels and Breast Cancer: A Nested Case-Control Study of Norwegian Women Cancer Epidemiol. Biomarkers Prev., December 1, 2000; 9(12): 1357 - 1367. [Abstract] [Full Text]

				S. D. Stellman, M. V. Djordjevic, J. A. Britton, J. E. Muscat, M. L. Citron, M. Kemeny, E. Busch, and L. Gong Breast Cancer Risk in Relation to Adipose Concentrations of Organochlorine Pesticides and Polychlorinated Biphenyls in Long Island, New York Cancer Epidemiol. Biomarkers Prev., November 1, 2000; 9(11): 1241 - 1249. [Abstract] [Full Text]