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Cancer Risk Estimates for Family Members of a Population-based Family Registry for Breast and Ovarian Cancer¹

Epidemiology Division, Department of Medicine, University of California, Irvine, Irvine, California 92697-7550 [A. Z., M. G., P. C., D. Br., T. H. T., S-Y. L., B. N., T. K., H. A-C.]; Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland 20892-7417 [D. S.]; Department of Physiology, University of Utah, Salt Lake City, Utah 84108 [D. Ba.]; Cleveland Clinic Foundation, Cleveland, Ohio 44195 [G. C.]; and Department of Preventive Medicine, University of Southern California, Los Angeles, California 90033 [R. H., D. T.]

Population-based breast and ovarian cancer family registries can facilitate studies to evaluate genetic and environmental factors in the etiology of these malignancies. The purpose of this study is to describe what is, as far as we know, the first population-based breast and ovarian cancer family registry and to estimate breast and ovarian cancer risk in relatives of breast and ovarian cancer probands. Population-based consecutive incident cases of breast and ovarian cancer were invited to participate in the University of California, Irvine breast and ovarian family registry. In this study, we report data on 1567 breast cancer and 328 ovarian cancer probands. The operational components of this family registry include enrollment of probands, family history interviewing, confidentiality, pathology, verification and review, biospecimen bank, statistical/genetic analysis, and special studies on positional cloning of known genes. All of the components are tracked through the University of California, Irvine Genetic Research Information System. In non-Hispanic-white breast cancer probands, relative risk (RR) of breast cancer in mothers and sisters is significantly elevated [RR = 1.7 and 95% confidence interval (CI) = 1.4–2.0 and RR = 2.8 and 95% CI = 2.3–3.3, respectively]. In families of ovarian cancer probands, mothers are at increased risk of ovarian cancer (RR = 4.6; 95% CI, 2.1–8.7). RR of breast cancer in mothers of Hispanic breast cancer probands is significantly elevated (RR = 4.9; 95% CI, 2.6–8.5). No elevation of breast or ovarian cancer risk was observed among relatives of Asian probands. In general, there is a decrease in RR among mothers and sisters with increase in age of onset of probands. In second-degree relatives and first cousins, the breast cancer hazards ratios increase with increase in the number of affected first-degree relatives and decrease with increase in age at onset of the proband.

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