| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Laboratory of Comparative Toxicology and Ecotoxicology, Istituto Superiore di Sanitá, 00161 Rome, Italy [M. D., A. C., E. D.]; Istituto Dermopatico dell’Immacolata, 00167 Rome, Italy [M. D., F. S., G. B., L. C., R. C., P. P.]; and Laboratory of Environmental Hygiene, Istituto Superiore di Sanitá, 00161 Rome, Italy [I. I.]
DNA repair capacity (DRC) was studied in 49 patients affected by basal cell carcinoma (BCC) and 68 cancer-free controls belonging to a larger case-control population enrolled for studying BCC risk factors. DRC was measured in the subjects’ peripheral blood lymphocytes by using a host-cell reactivation assay that measures cellular activation of a reporter gene irradiated with UV light. A statistically significant age-related decline in DRC was observed in the controls from 20 to 70 years of age but not in the BCC cases. When the DRC values of the BCC patients and controls were compared by age, young BCC cases (age, 
40 year) repaired less than the controls, although the difference was not statistically significant. Conversely, older BCC patients (age, >40 years) presented an enhanced repair capacity (P < 0.001) as compared with their controls. The search for possible factors associated with the high repair rate of elderly BCC cases revealed that both target cell physiology and life-style habits may affect host DNA repair. Smoking was the variable that explained most of the increase in DRC among older patients. The understanding of how these factors affect host DRC will be relevant for a correct use of this biomarker.
This article has been cited by other articles:
|
|
 |
|
  L.-E Wang, C. Li, S. S. Strom, L. H. Goldberg, A. Brewster, Z. Guo, Y. Qiao, G. L. Clayman, J. J. Lee, A. K. El-Naggar, et al. Repair Capacity for UV Light Induced DNA Damage Associated with Risk of Nonmelanoma Skin Cancer and Tumor Progression Clin. Cancer Res., November 1, 2007; 13(21): 6532 - 6539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Zijno, F. Saini, and R. Crebelli Suitability of cryopreserved isolated lymphocytes for the analysis of micronuclei with the cytokinesis-block method Mutagenesis, September 1, 2007; 22(5): 311 - 315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wang, Q. Wei, Q. Shi, Z. Guo, Y. Qiao, and M. R. Spitz A modified host-cell reactivation assay to measure repair of alkylating DNA damage for assessing risk of lung adenocarcinoma Carcinogenesis, July 1, 2007; 28(7): 1430 - 1436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Shen, M. Desai, M. Agrawal, D. O. Kennedy, R. T. Senie, R. M. Santella, and M. B. Terry Polymorphisms in nucleotide excision repair genes and DNA repair capacity phenotype in sisters discordant for breast cancer. Cancer Epidemiol. Biomarkers Prev., September 1, 2006; 15(9): 1614 - 1619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. O. Kennedy, M. Agrawal, J. Shen, M. B. Terry, F. F. Zhang, R. T. Senie, G. Motykiewicz, and R. M. Santella DNA Repair Capacity of Lymphoblastoid Cell Lines From Sisters Discordant for Breast Cancer J Natl Cancer Inst, January 19, 2005; 97(2): 127 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.-H. Wong, C.-L. Du, J.-D. Wang, C.-C. Chan, J.-C. J. Luo, and T.-J. Cheng XRCC1 and CYP2E1 Polymorphisms as Susceptibility Factors of Plasma Mutant p53 Protein and Anti-p53 Antibody Expression in Vinyl Chloride Monomer-exposed Polyvinyl Chloride Workers Cancer Epidemiol. Biomarkers Prev., May 1, 2002; 11(5): 475 - 482. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Cell Growth & Differentiation |
