| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Short Communication |
Departments of Community and Family Medicine [J. M. S.] and Surgery [W. D-W.], Duke University Medical Center, Durham, North Carolina 27710; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27515 [E. D., B. N.]; Cedars-Sinai Medical Center, Center for Women’s Health, Los Angeles, California 90048 [C. H.]; and AccuChem Laboratories, Richardson, Texas 75081 [J. L. L.]
The effect of body mass index (BMI) and waist:hip ratio (WHR) on plasma levels of organochlorines [i.e., 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE)] was investigated in a sample of black and white women drawn from a population-based study in North Carolina. Organochlorine levels were determined in plasma samples from 99 women selected on the basis of race (black versus white) and quartile of the WHR (1st versus 4th). Of a panel of 20 organochlorine compounds tested, only DDE was detectable in most study subjects. Measurements of height, weight, and waist and hip circumferences were taken during an in-person interview. Information was elicited regarding dietary, residential, and breast-feeding histories. Results of multiple regression analyses indicate that black women had significantly higher plasma levels of DDE than white women. These levels were independent of BMI and WHR. BMI but not WHR was also found to be an independent predictor of DDE plasma level. These results suggest that black/white differences should be considered in studies that explore the relationship between environmental contaminants and various disease outcomes, such as breast cancer risk. In addition, BMI may affect circulating levels of contaminants and should also be considered a potentially important modifying factor for exposure to lipophilic substances.
This article has been cited by other articles:
|
|
 |
|
  M. S. Wolff, H. A. Anderson, J. A. Britton, and N. Rothman Pharmacokinetic Variability and Modern Epidemiology The Example of Dichlorodiphenyltrichloroethane, Body Mass Index, and Birth Cohort Cancer Epidemiol. Biomarkers Prev., October 1, 2007; 16(10): 1925 - 1930. [Full Text] [PDF]
|
|
|
|
|
|
J. R. Palmer, L. L. Adams-Campbell, D. A. Boggs, L. A. Wise, and L. Rosenberg A Prospective Study of Body Size and Breast Cancer in Black Women Cancer Epidemiol. Biomarkers Prev., September 1, 2007; 16(9): 1795 - 1802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Perry, F. Ouyang, S. Korrick, S. A. Venners, L. Altshul, X. Xu, and X. Wang Body Mass Index and Serum 1,1,1-Trichloro-2,2-Bis(p-Chlorophenyl)Ethane in Nulliparous Chinese Women Cancer Epidemiol. Biomarkers Prev., October 1, 2005; 14(10): 2433 - 2438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Wolff, J. A. Britton, S. L. Teitelbaum, S. Eng, E. Deych, K. Ireland, Z. Liu, A. I. Neugut, R. M. Santella, and M. D. Gammon Improving Organochlorine Biomarker Models for Cancer Research Cancer Epidemiol. Biomarkers Prev., September 1, 2005; 14(9): 2224 - 2236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. V. Magnusdottir, T. Thorsteinsson, S. Thorsteinsdottir, M. Heimisdottir, and K. Olafsdottir Persistent organochlorines, sedentary occupation, obesity and human male subfertility Hum. Reprod., January 1, 2005; 20(1): 208 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pirozzo, D. Purdie, M. Kuiper-Linley, P. Webb, P. Harvey, A. Green, and C. Bain Ovarian Cancer, Cholesterol, and Eggs: A Case-Control Analysis Cancer Epidemiol. Biomarkers Prev., October 1, 2002; 11(10): 1112 - 1114. [Full Text] [PDF]
|
|
|
|
|
|
M. D. Gammon, M. S. Wolff, A. I. Neugut, S. M. Eng, S. L. Teitelbaum, J. A. Britton, M. B. Terry, B. Levin, S. D. Stellman, G. C. Kabat, et al. Environmental Toxins and Breast Cancer on Long Island. II. Organochlorine Compound Levels in Blood Cancer Epidemiol. Biomarkers Prev., August 1, 2002; 11(8): 686 - 697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. L. Godschalk, D. E. M. Feldker, P. J. A. Borm, E. F. M. Wouters, and F.-J. Van Schooten Body Mass Index Modulates Aromatic DNA Adduct Levels and Their Persistence in Smokers Cancer Epidemiol. Biomarkers Prev., August 1, 2002; 11(8): 790 - 793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Laden, G. Collman, K. Iwamoto, A. J. Alberg, G. S. Berkowitz, J. L. Freudenheim, S. E. Hankinson, K. J. Helzlsouer, T. R. Holford, H.-Y. Huang, et al. 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and Polychlorinated Biphenyls and Breast Cancer: Combined Analysis of Five U.S. Studies J Natl Cancer Inst, May 16, 2001; 93(10): 768 - 775. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Vine, L. Stein, K. Weigle, J. Schroeder, D. Degnan, C.-K. J. Tse, and L. Backer Plasma 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) Levels and Immune Response Am. J. Epidemiol., January 1, 2001; 153(1): 53 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Wolff, A. Zeleniuch-Jacquotte, N. Dubin, and P. Toniolo Risk of Breast Cancer and Organochlorine Exposure Cancer Epidemiol. Biomarkers Prev., March 1, 2000; 9(3): 271 - 277. [Abstract] [Full Text]
|
|
|
|
|
|
M. S. Wolff and H. A. Anderson Correspondence re: J. M. Schildkraut et al., Environmental Contaminants and Body Fat Distribution. Cancer Epidemiol. Biomark. Prev., 8: 179-183, 1999 Cancer Epidemiol. Biomarkers Prev., October 1, 1999; 8(10): 951 - 952. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Cell Growth & Differentiation |
