CEBP Meeting Calendar Targets
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dunning, A. M.
Right arrow Articles by Easton, D. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dunning, A. M.
Right arrow Articles by Easton, D. F.
Cancer Epidemiology Biomarkers & Prevention Vol. 8, 843-854, October 1999
© 1999 American Association for Cancer Research

Review

A Systematic Review Of Genetic Polymorphisms and Breast Cancer Risk1

Alison M. Dunning2, Catherine S. Healey2, Paul D. P. Pharoah2,, 3, M. Dawn Teare2, Bruce A. J. Ponder and Douglas F. Easton

Cancer Research Campaign Human Cancer Genetics Group, University Department of Oncology [A. M. D., C. S. H., P. D. P. P., B. A. J. P.], and Cancer Research Campaign Genetic Epidemiology Group, University Department of Community Medicine [M. D. T., D. F. E.], Strangeways Research Laboratories, Worts Causeway, Cambridge CB1 8RN, United Kingdom

Studies investigating the relationship between common genetic variants and cancer risk are being reported with rapidly increasing frequency. We have identified 46 published case-control studies that have examined the effect of common alleles of 18 different genes on breast cancer risk. Of these, 12 report statistically significant associations, none of which were reported by more than one study. However, many of the studies were small: 10 of the 46 had 80% power or greater to detect a rare allele homozygote relative risk <2.5. We therefore combined the results of individual studies to obtain more precise estimates of risk. Statistically significant differences in genotype frequencies were found in three case-control comparisons of unselected cases. These were for CYP19 (TTTA)n polymorphism [(TTTA)10 carrier odds ratio (OR) = 2.33; P = 0.002], the GSTP1 Ile105Val polymorphism (Val carrier OR = 1.60; P = 0.02), and the TP53 Arg72Pro polymorphism (Pro carrier OR = 1.27; P = 0.03). In addition, the GSTM1 gene deletion was found to be significantly associated with postmenopausal breast cancer (null homozygote OR = 1.33; P = 0.04). There was also some evidence that homozygotes for the PR PROGINS allele are protected against breast cancer, although this result was of borderline statistical significance. For polymorphisms in BRCA1, COMT, CYP17, CYP1A1, NAT1, and NAT2, the best estimate of risk either from the individual studies or the meta-analyses was sufficiently precise to exclude a relative risk of 1.5 or greater. For the polymorphisms in EDH17B2, ER, CYP2D6, CYP2E1, GSTT1, HSP70, and TNF{alpha}, the risk estimates, although nonsignificant, were insufficiently precise to exclude a moderate risk (>1.5). Precise estimation of the risks associated with these and other as yet untested genes, as well as investigation of more complex risks arising from gene-gene and gene-environment interactions, will require much larger studies.




This article has been cited by other articles:


Home page
 FASEB J.Home page
K.-D. Yu, G.-H. Di, L. Fan, J. Wu, Z. Hu, Z.-Z. Shen, W. Huang, and Z.-M. Shao
A functional polymorphism in the promoter region of GSTM1 implies a complex role for GSTM1 in breast cancer
FASEB J, July 1, 2009; 23(7): 2274 - 2287.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
Y.-S. Hong, S. L. Deming, Y.-T. Gao, J.-R. Long, X.-O. Shu, Q. Cai, W. Lu, and W. Zheng
A Two-stage Case-Control Study of EGFR Polymorphisms and Breast Cancer Risk
Cancer Epidemiol. Biomarkers Prev., February 1, 2009; 18(2): 680 - 683.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
V. O. Dezentje, H.-J. Guchelaar, J. W.R. Nortier, C. J.H. van de Velde, and H. Gelderblom
Clinical Implications of CYP2D6 Genotyping in Tamoxifen Treatment for Breast Cancer
Clin. Cancer Res., January 1, 2009; 15(1): 15 - 21.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
M. Hamaguchi, M. Nishio, T. Toyama, H. Sugiura, N. Kondo, Y. Fujii, and H. Yamashita
Possible Difference in Frequencies of Genetic Polymorphisms of Estrogen Receptor {alpha}, Estrogen Metabolism and P53 Genes Between Estrogen Receptor-positive and -negative Breast Cancers
Jpn. J. Clin. Oncol., November 1, 2008; 38(11): 734 - 742.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
W. G. Newman, K. D. Hadfield, A. Latif, S. A. Roberts, A. Shenton, C. McHague, F. Lalloo, S. Howell, and D. G. Evans
Impaired Tamoxifen Metabolism Reduces Survival in Familial Breast Cancer Patients
Clin. Cancer Res., September 15, 2008; 14(18): 5913 - 5918.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
B. Diergaarde, J. D. Potter, E. R. Jupe, S. Manjeshwar, C. D. Shimasaki, T. W. Pugh, D. C. DeFreese, B. A. Gramling, I. Evans, and E. White
Polymorphisms in Genes Involved in Sex Hormone Metabolism, Estrogen Plus Progestin Hormone Therapy Use, and Risk of Postmenopausal Breast Cancer
Cancer Epidemiol. Biomarkers Prev., July 1, 2008; 17(7): 1751 - 1759.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. Gold, T. Kirchhoff, S. Stefanov, J. Lautenberger, A. Viale, J. Garber, E. Friedman, S. Narod, A. B. Olshen, P. Gregersen, et al.
Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33
PNAS, March 18, 2008; 105(11): 4340 - 4345.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
Q. Cai, N. Kataoka, C. Li, W. Wen, J. R. Smith, Y.-T. Gao, X. O. Shu, and W. Zheng
Haplotype Analyses of CYP19A1 Gene Variants and Breast Cancer Risk: Results from the Shanghai Breast Cancer Study
Cancer Epidemiol. Biomarkers Prev., January 1, 2008; 17(1): 27 - 32.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
V. W. Setiawan, F. R. Schumacher, C. A. Haiman, D. O. Stram, D. Albanes, D. Altshuler, G. Berglund, J. Buring, E. E. Calle, F. Clavel-Chapelon, et al.
CYP17 Genetic Variation and Risk of Breast and Prostate Cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2237 - 2246.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
K. D. Crew, M. D. Gammon, M. B. Terry, F. F. Zhang, L. B. Zablotska, M. Agrawal, J. Shen, C.-M. Long, S. M. Eng, S. K. Sagiv, et al.
Polymorphisms in Nucleotide Excision Repair Genes, Polycyclic Aromatic Hydrocarbon-DNA Adducts, and Breast Cancer Risk
Cancer Epidemiol. Biomarkers Prev., October 1, 2007; 16(10): 2033 - 2041.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
B. Zhang, T. Sun, L. Xue, X. Han, B. Zhang, N. Lu, Y. Shi, W. Tan, Y. Zhou, D. Zhao, et al.
Functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer
Carcinogenesis, May 1, 2007; 28(5): 1067 - 1073.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
A. Romano, B. Delvoux, D.-C. Fischer, and P. Groothuis
The PROGINS polymorphism of the human progesterone receptor diminishes the response to progesterone
J. Mol. Endocrinol., February 1, 2007; 38(2): 331 - 350.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
Y.-Y. Hsieh, Y.-K. Wang, C.-C. Chang, and C.-S. Lin
Estrogen receptor {alpha}-351 XbaIG and -397 PvuIIC-related genotypes and alleles are associated with higher susceptibilities of endometriosis and leiomyoma
Mol. Hum. Reprod., February 1, 2007; 13(2): 117 - 122.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
W. M. Howell and M. J. Rose-Zerilli
Cytokine Gene Polymorphisms, Cancer Susceptibility, and Prognosis
J. Nutr., January 1, 2007; 137(1): 194S - 199S.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
K. Dahlman-Wright, V. Cavailles, S. A. Fuqua, V. C. Jordan, J. A. Katzenellenbogen, K. S. Korach, A. Maggi, M. Muramatsu, M. G. Parker, and J.-A. Gustafsson
International Union of Pharmacology. LXIV. Estrogen Receptors
Pharmacol. Rev., December 1, 2006; 58(4): 773 - 781.
[Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
P. S. Crooke, M. D. Ritchie, D. L. Hachey, S. Dawling, N. Roodi, and F. F. Parl
Estrogens, enzyme variants, and breast cancer: a risk model.
Cancer Epidemiol. Biomarkers Prev., September 1, 2006; 15(9): 1620 - 1629.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. Wirtenberger, B. Frank, K. Hemminki, R. Klaes, R. K. Schmutzler, B. Wappenschmidt, A. Meindl, M. Kiechle, N. Arnold, B. H.F. Weber, et al.
Interaction of Werner and Bloom syndrome genes with p53 in familial breast cancer
Carcinogenesis, August 1, 2006; 27(8): 1655 - 1660.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
O. Fletcher, N. Johnson, C. Palles, I. dos Santos Silva, V. McCormack, J. Whittaker, A. Ashworth, and J. Peto
Inconsistent association between the STK15 F31I genetic polymorphism and breast cancer risk.
J Natl Cancer Inst, July 19, 2006; 98(14): 1014 - 1018.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
K. A. Pooley, C. S. Healey, P. L. Smith, P. D.P. Pharoah, D. Thompson, L. Tee, J. West, C. Jordan, D. F. Easton, B. A.J. Ponder, et al.
Association of the progesterone receptor gene with breast cancer risk: a single-nucleotide polymorphism tagging approach.
Cancer Epidemiol. Biomarkers Prev., April 1, 2006; 15(4): 675 - 682.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. Guarducci, F. Nuti, L. Becherini, M. Rotondi, G. Balercia, G. Forti, and C. Krausz
Estrogen receptor {alpha} promoter polymorphism: stronger estrogen action is coupled with lower sperm count
Hum. Reprod., April 1, 2006; 21(4): 994 - 1001.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
P. W. Parodi
Dairy Product Consumption and the Risk of Breast Cancer
J. Am. Coll. Nutr., December 1, 2005; 24(suppl_6): 556S - 568S.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
M. S. Cicek, X. Liu, G. Casey, and J. S. Witte
Role of Androgen Metabolism Genes CYP1B1, PSA/KLK3, and CYP11{alpha} in Prostate Cancer Risk and Aggressiveness
Cancer Epidemiol. Biomarkers Prev., September 1, 2005; 14(9): 2173 - 2177.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
L. Le Marchand, T. Donlon, L. N. Kolonel, B. E. Henderson, and L. R. Wilkens
Estrogen Metabolism-Related Genes and Breast Cancer Risk: The Multiethnic Cohort Study
Cancer Epidemiol. Biomarkers Prev., August 1, 2005; 14(8): 1998 - 2003.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
J.-Y. Choi, K.-M. Lee, S. K. Park, D.-Y. Noh, S.-H. Ahn, H.-W. Chung, W. Han, J. S. Kim, S. G. Shin, I.-J. Jang, et al.
Genetic Polymorphisms of SULT1A1 and SULT1E1 and the Risk and Survival of Breast Cancer
Cancer Epidemiol. Biomarkers Prev., May 1, 2005; 14(5): 1090 - 1095.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
A. Baida, S. M. Farrington, P. Galofre, R. Marcos, and A. Velazquez
Thyroid Cancer Susceptibility and THRA1 and BAT-40 Repeats Polymorphisms
Cancer Epidemiol. Biomarkers Prev., March 1, 2005; 14(3): 638 - 642.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
L. Gennari, D. Merlotti, V. De Paola, A. Calabro, L. Becherini, G. Martini, and R. Nuti
Estrogen Receptor Gene Polymorphisms and the Genetics of Osteoporosis: A HuGE Review
Am. J. Epidemiol., February 15, 2005; 161(4): 307 - 320.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Kammerer, R. B. Roth, C. R. Hoyal, R. Reneland, G. Marnellos, M. Kiechle, U. Schwarz-Boeger, L. R. Griffiths, F. Ebner, J. Rehbock, et al.
Association of the NuMA region on chromosome 11q13 with breast cancer susceptibility
PNAS, February 8, 2005; 102(6): 2004 - 2009.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
B. K. Dunn, D. L. Wickerham, and L. G. Ford
Prevention of Hormone-Related Cancers: Breast Cancer
J. Clin. Oncol., January 10, 2005; 23(2): 357 - 367.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
C. L. Pearce, J. N. Hirschhorn, A. H. Wu, N. P. Burtt, D. O. Stram, S. Young, L. N. Kolonel, B. E. Henderson, D. Altshuler, and M. C. Pike
Clarifying the PROGINS Allele Association in Ovarian and Breast Cancer Risk: A Haplotype-Based Analysis
J Natl Cancer Inst, January 5, 2005; 97(1): 51 - 59.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
S-W Kim, C S Lee, J V Fey, P I Borgen, and J Boyd
Prevalence of BRCA2 mutations in a hospital based series of unselected breast cancer cases
J. Med. Genet., January 1, 2005; 42(1): e5 - e5.
[Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
S. E. Hur, J. Y. Lee, H.-S. Moon, and H. W. Chung
Polymorphisms of the genes encoding the GSTM1, GSTT1 and GSTP1 in Korean women: no association with endometriosis
Mol. Hum. Reprod., January 1, 2005; 11(1): 15 - 19.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
R. C. Travis, M. Churchman, S. A. Edwards, G. Smith, P. K. Verkasalo, C. R. Wolf, H. Wolf, and T. J. Key
No Association of Polymorphisms in CYP17, CYP19, and HSD17-B1 with Plasma Estradiol Concentrations in 1,090 British Women
Cancer Epidemiol. Biomarkers Prev., December 1, 2004; 13(12): 2282 - 2284.
[Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. Gago-Dominguez, J.E. Castelao, C.-L. Sun, D. Van Den Berg, W.-P. Koh, H.-P. Lee, and M. C. Yu
Marine n-3 fatty acid intake, glutathione S-transferase polymorphisms and breast cancer risk in post-menopausal Chinese women in Singapore
Carcinogenesis, November 1, 2004; 25(11): 2143 - 2147.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. Rollinson, J. M. Allan, G. R. Law, P. L. Roddam, M. T. Smith, C. Skibola, A. G. Smith, M. S. Forrest, K. Sibley, R. Higuchi, et al.
High-Throughput Association Testing on DNA Pools to Identify Genetic Variants that Confer Susceptibility to Acute Myeloid Leukemia
Cancer Epidemiol. Biomarkers Prev., May 1, 2004; 13(5): 795 - 800.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. McGrath, S. E. Hankinson, L. Arbeitman, G. A. Colditz, D. J. Hunter, and I. De Vivo
Cytochrome P450 1B1 and catechol-O-methyltransferase polymorphisms and endometrial cancer susceptibility
Carcinogenesis, April 1, 2004; 25(4): 559 - 565.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Roodi, W. D. Dupont, J. H. Moore, and F. F. Parl
Association of Homozygous Wild-Type Glutathione S-Transferase M1 Genotype with Increased Breast Cancer Risk
Cancer Res., February 15, 2004; 64(4): 1233 - 1236.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
K. M. Egan, Q. Cai, X.-O. Shu, F. Jin, T.-L. Zhu, Q. Dai, Y.-T. Gao, and W. Zheng
Genetic Polymorphisms in GSTM1, GSTP1, and GSTT1 and the Risk for Breast Cancer: Results from the Shanghai Breast Cancer Study and Meta-Analysis
Cancer Epidemiol. Biomarkers Prev., February 1, 2004; 13(2): 197 - 204.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. S. Tworoger, J. Chubak, E. J. Aiello, C. M. Ulrich, C. Atkinson, J. D. Potter, Y. Yasui, P. L. Stapleton, J. W. Lampe, F. M. Farin, et al.
Association of CYP17, CYP19, CYP1B1, and COMT Polymorphisms with Serum and Urinary Sex Hormone Concentrations in Postmenopausal Women
Cancer Epidemiol. Biomarkers Prev., January 1, 2004; 13(1): 94 - 101.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. Brandt, S. Hermann, K. Straif, N. Tidow, H. Buerger, and J. Chang-Claude
Modification of Breast Cancer Risk in Young Women by a Polymorphic Sequence in the egfr Gene
Cancer Res., January 1, 2004; 64(1): 7 - 12.
[Abstract] [Full Text] [PDF]

Home page
 International Journal of ToxicologyHome page
N. A. Kocabas, S. Sardas, S. Cholerton, A. K. Daly, and A. E. Karakaya
N-Acetyltransferase (NAT2) Polymorphism and Breast Cancer Susceptibility: A Lack of Association in a Case-Control Study of Turkish Population
International Journal of Toxicology, January 1, 2004; 23(1): 25 - 31.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
N. Moullan, D. G. Cox, S. Angele, P. Romestaing, J.-P. Gerard, and J. Hall
Polymorphisms in the DNA Repair Gene XRCC1, Breast Cancer Risk, and Response to Radiotherapy
Cancer Epidemiol. Biomarkers Prev., November 1, 2003; 12(11): 1168 - 1174.
[Abstract] [Full Text]

Home page
 Mol Hum ReprodHome page
F. Sata, H. Yamada, A. Yamada, E. H. Kato, S. Kataoka, Y. Saijo, T. Kondo, J. Tamaki, H. Minakami, and R. Kishi
A polymorphism in the CYP17 gene relates to the risk of recurrent pregnancy loss
Mol. Hum. Reprod., November 1, 2003; 9(11): 725 - 728.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. H. Fowke, F.-L. Chung, F. Jin, D. Qi, Q. Cai, C. Conaway, J.-R. Cheng, X.-O. Shu, Y.-T. Gao, and W. Zheng
Urinary Isothiocyanate Levels, Brassica, and Human Breast Cancer
Cancer Res., July 15, 2003; 63(14): 3980 - 3986.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
R. Wooster and B. L. Weber
Breast and Ovarian Cancer
N. Engl. J. Med., June 5, 2003; 348(23): 2339 - 2347.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
Y.-P. Fu, J.-C. Yu, T.-C. Cheng, M. A. Lou, G.-C. Hsu, C.-Y. Wu, S.-T. Chen, H.-S. Wu, P.-E. Wu, and C.-Y. Shen
Breast Cancer Risk Associated with Genotypic Polymorphism of the Nonhomologous End-Joining Genes: A Multigenic Study on Cancer Susceptibility
Cancer Res., May 15, 2003; 63(10): 2440 - 2446.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
B. A. Nexo, U. Vogel, A. Olsen, T. Ketelsen, Z. Bukowy, B. L. Thomsen, H. Wallin, K. Overvad, and A. Tjonneland
A specific haplotype of single nucleotide polymorphisms on chromosome 19q13.2-3 encompassing the gene RAI is indicative of post-menopausal breast cancer before age 55
Carcinogenesis, May 1, 2003; 24(5): 899 - 904.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
B. F. El-Rayes, S. Ali, L. K. Heilbrun, S. Lababidi, D. Bouwman, D. Visscher, and P. A. Philip
Cytochrome P450 and Glutathione Transferase Expression in Human Breast Cancer
Clin. Cancer Res., May 1, 2003; 9(5): 1705 - 1709.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
E. Ziv, J. Shepherd, R. Smith-Bindman, and K. Kerlikowske
Mammographic Breast Density and Family History of Breast Cancer
J Natl Cancer Inst, April 2, 2003; 95(7): 556 - 558.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
B. Faraglia, S. Y. Chen, M. D. Gammon, Y. Zhang, S. L. Teitelbaum, A. I. Neugut, H. Ahsan, G. C. Garbowski, H. Hibshoosh, D. Lin, et al.
Evaluation of 4-aminobiphenyl-DNA adducts in human breast cancer: the influence of tobacco smoke
Carcinogenesis, April 1, 2003; 24(4): 719 - 725.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Ishitobi, Y. Miyoshi, A. Ando, S. Hasegawa, C. Egawa, Y. Tamaki, M. Monden, and S. Noguchi
Association of BRCA2 Polymorphism at Codon 784 (Met/Val) with Breast Cancer Risk and Prognosis
Clin. Cancer Res., April 1, 2003; 9(4): 1376 - 1380.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
N. E. Caporaso
Why Have We Failed to Find the Low Penetrance Genetic Constituents of Common Cancers?
Cancer Epidemiol. Biomarkers Prev., December 1, 2002; 11(12): 1544 - 1549.
[Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
M. M. de Jong, I. M. Nolte, G. J. te Meerman, W. T. A. van der Graaf, E. G. E. de Vries, R. H. Sijmons, R. M. W. Hofstra, and J. H. Kleibeuker
Low-penetrance Genes and Their Involvement in Colorectal Cancer Susceptibility
Cancer Epidemiol. Biomarkers Prev., November 1, 2002; 11(11): 1332 - 1352.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
P. Greenwald
Cancer Prevention Clinical Trials
J. Clin. Oncol., September 15, 2002; 20(90001): 14s - 22.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
Z. Ye and J. M. Parry
Concerning the CYP17 MSPA1 polymorphism and breast cancer risk: a meta-analysis
Mutagenesis, September 1, 2002; 17(5): 447 - 448.
[Full Text] [PDF]

Home page
 CarcinogenesisHome page
A. Forsti, Q. Jin, E. Grzybowska, M. Soderberg, H. Zientek, M. Sieminska, J. Rogozinska-Szczepka, E. Chmielik, B. Utracka-Hutka, and K. Hemminki
Sex hormone-binding globulin polymorphisms in familial and sporadic breast cancer
Carcinogenesis, August 1, 2002; 23(8): 1315 - 1320.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
H Tulinius, G H Olafsdottir, H Sigvaldason, A Arason, R B Barkardottir, V Egilsson, H M Ogmundsdottir, L Tryggvadottir, S Gudlaugsdottir, and J E Eyfjord
The effect of a single BRCA2 mutation on cancer in Iceland
J. Med. Genet., July 1, 2002; 39(7): 457 - 462.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. L. Goode, A. M. Dunning, B. Kuschel, C. S. Healey, N. E. Day, B. A. J. Ponder, D. F. Easton, and P. P. D. Pharoah
Effect of Germ-Line Genetic Variation on Breast Cancer Survival in a Population-based Study
Cancer Res., June 1, 2002; 62(11): 3052 - 3057.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
K. L. Nathanson, Y. Y. Shugart, R. Omaruddin, C. Szabo, D. Goldgar, T. R. Rebbeck, and B. L. Weber
CGH-targeted linkage analysis reveals a possible BRCA1 modifier locus on chromosome 5q
Hum. Mol. Genet., May 16, 2002; 11(11): 1327 - 1332.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
M M de Jong, I M Nolte, G J te Meerman, W T A van der Graaf, J C Oosterwijk, J H Kleibeuker, M Schaapveld, and E G E de Vries
Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility
J. Med. Genet., April 1, 2002; 39(4): 225 - 242.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
Z. Ye and J. M. Parry
The CYP17 MspA1 polymorphism and breast cancer risk: a meta-analysis
Mutagenesis, March 1, 2002; 17(2): 119 - 126.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
P. F. Firozi, M. L. Bondy, A. A. Sahin, P. Chang, F. Lukmanji, E. S. Singletary, M. M. Hassan, and D. Li
Aromatic DNA adducts and polymorphisms of CYP1A1, NAT2, and GSTM1 in breast cancer
Carcinogenesis, February 1, 2002; 23(2): 301 - 306.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
B. L. Powell, I. L. van Staveren, P. Roosken, F. Grieu, E. M.J.J. Berns, and B. Iacopetta
Associations between common polymorphisms in TP53 and p21WAF1/Cip1 and phenotypic features of breast cancer
Carcinogenesis, February 1, 2002; 23(2): 311 - 315.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
M. Zhao, R. Lewis, D. R. Gustafson, W.-Q. Wen, J. R. Cerhan, and W. Zheng
No Apparent Association of GSTP1 A313G Polymorphism with Breast Cancer Risk among Postmenopausal Iowa Women
Cancer Epidemiol. Biomarkers Prev., December 1, 2001; 10(12): 1301 - 1302.
[Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
K. Gudmundsdottir, L. Tryggvadottir, and J. E. Eyfjord
GSTM1, GSTT1, and GSTP1 Genotypes in Relation to Breast Cancer Risk and Frequency of Mutations in the p53 Gene
Cancer Epidemiol. Biomarkers Prev., November 1, 2001; 10(11): 1169 - 1173.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. B. Ambrosone, C. Sweeney, B. F. Coles, P. A. Thompson, G. Y. McClure, S. Korourian, M. Y. Fares, A. Stone, F. F. Kadlubar, and L. F. Hutchins
Polymorphisms in Glutathione S-Transferases (GSTM1 and GSTT1) and Survival after Treatment for Breast Cancer
Cancer Res., October 1, 2001; 61(19): 7130 - 7135.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Giguere, E. Dewailly, J. Brisson, P. Ayotte, N. Laflamme, A. Demers, V.-I. Forest, S. Dodin, J. Robert, and F. Rousseau
Short Polyglutamine Tracts in the Androgen Receptor Are Protective against Breast Cancer in the General Population
Cancer Res., August 1, 2001; 61(15): 5869 - 5874.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
C. A. Haiman, M. J. Stampfer, E. Giovannucci, J. Ma, N. E. Decalo, P. W. Kantoff, and D. J. Hunter
The Relationship between a Polymorphism in CYP17 with Plasma Hormone Levels and Prostate Cancer
Cancer Epidemiol. Biomarkers Prev., July 1, 2001; 10(7): 743 - 748.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
E. Ziv, J. Cauley, P. A. Morin, R. Saiz, and W. S. Browner
Association Between the T29->C Polymorphism in the Transforming Growth Factor {beta}1 Gene and Breast Cancer Among Elderly White Women: The Study of Osteoporotic Fractures
JAMA, June 13, 2001; 285(22): 2859 - 2863.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
K. Armstrong
Genetic Susceptibility to Breast Cancer: From the Roll of the Dice to the Hand Women Were Dealt
JAMA, June 13, 2001; 285(22): 2907 - 2909.
[Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
K. Mitrunen, N. Jourenkova, V. Kataja, M. Eskelinen, V.-M. Kosma, S. Benhamou, D. Kang, H. Vainio, M. Uusitupa, and A. Hirvonen
Polymorphic Catechol-O-methyltransferase Gene and Breast Cancer Risk
Cancer Epidemiol. Biomarkers Prev., June 1, 2001; 10(6): 635 - 640.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. A. Haiman, S. E. Hankinson, G. A. Colditz, D. J. Hunter, and I. De Vivo
A Polymorphism in CYP17 and Endometrial Cancer Risk
Cancer Res., May 1, 2001; 61(10): 3955 - 3960.
[Abstract] [Full Text]

Home page
 Hum Mol GenetHome page
K. L. Nathanson and B. L. Weber
'Other' breast cancer susceptibility genes: searching for more holy grail
Hum. Mol. Genet., April 1, 2001; 10(7): 715 - 720.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
K. Mitrunen, N. Jourenkova, V. Kataja, M. Eskelinen, V.-M. Kosma, S. Benhamou, H. Vainio, M. Uusitupa, and A. Hirvonen
Glutathione S-Transferase M1, M3, P1, and T1 Genetic Polymorphisms and Susceptibility to Breast Cancer
Cancer Epidemiol. Biomarkers Prev., March 1, 2001; 10(3): 229 - 236.
[Abstract] [Full Text]

Home page
 CarcinogenesisHome page
S.W. Baxter, D.Y.H. Choong, D.M. Eccles, and I.G. Campbell
Polymorphic variation in CYP19 and the risk of breast cancer
Carcinogenesis, February 1, 2001; 22(2): 347 - 349.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S.W. Baxter, E.J. Thomas, and I.G. Campbell
GSTM1 null polymorphism and susceptibility to endometriosis and ovarian cancer
Carcinogenesis, January 1, 2001; 22(1): 63 - 66.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
A. B. Spurdle, P. M. Webb, D. M. Purdie, X. Chen, A. Green, and G. Chenevix-Trench
Polymorphisms at the glutathione S-transferase GSTM1, GSTT1 and GSTP1 loci: risk of ovarian cancer by histological subtype
Carcinogenesis, January 1, 2001; 22(1): 67 - 72.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
D. A. Lawlor, K. L. Beebe, R. Zaninelli, B. Trock, M. Cotterchio, and N. Kreiger
RE: "ANTIDEPRESSANT MEDICATION USE AND BREAST CANCER RISK"
Am. J. Epidemiol., December 1, 2000; 152(11): 1104 - 1016.
[Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. D. Stellman, M. V. Djordjevic, J. A. Britton, J. E. Muscat, M. L. Citron, M. Kemeny, E. Busch, and L. Gong
Breast Cancer Risk in Relation to Adipose Concentrations of Organochlorine Pesticides and Polychlorinated Biphenyls in Long Island, New York
Cancer Epidemiol. Biomarkers Prev., November 1, 2000; 9(11): 1241 - 1249.
[Abstract] [Full Text]

Home page
 CarcinogenesisHome page
R. Goth-Goldstein, M. R. Stampfer, C. A. Erdmann, and M. Russell
Interindividual variation in CYP1A1 expression in breast tissue and the role of genetic polymorphism
Carcinogenesis, November 1, 2000; 21(11): 2119 - 2122.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
A. B. Spurdle, J. L. Hopper, G. S. Dite, X. Chen, J. Cui, M. R. E. McCredie, G. G. Giles, M. C. Southey, D. J. Venter, D. F. Easton, et al.
CYP17 Promoter Polymorphism and Breast Cancer in Australian Women Under Age Forty Years
J Natl Cancer Inst, October 18, 2000; 92(20): 1674 - 1681.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
A. C. Deitz, W. Zheng, M. A. Leff, M. Gross, W.-Q. Wen, M. A. Doll, G. H. Xiao, A. R. Folsom, and D. W. Hein
N-Acetyltransferase-2 Genetic Polymorphism, Well-done Meat Intake, and Breast Cancer Risk among Postmenopausal Women
Cancer Epidemiol. Biomarkers Prev., September 1, 2000; 9(9): 905 - 910.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
J. A. Williams and D. H. Phillips
Mammary Expression of Xenobiotic Metabolizing Enzymes and Their Potential Role in Breast Cancer
Cancer Res., September 1, 2000; 60(17): 4667 - 4677.
[Abstract] [Full Text]

Home page
 J Natl Cancer Inst MonogrHome page
P. A. Thompson and C. Ambrosone
Chapter 7: Molecular Epidemiology of Genetic Polymorphisms in Estrogen Metabolizing Enzymes in Human Breast Cancer
J Natl Cancer Inst Monographs, July 1, 2000; 2000(27): 125 - 134.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.