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Cancer Epidemiology Biomarkers & Prevention, Vol 6, Issue 7 551-552, Copyright © 1997 by American Association for Cancer Research
ARTICLES |
FD Groves, L Zhang, JY Li, WC You, YS Chang, L Zhao, WD Liu, CS Rabkin, GI Perez-Perez, MJ Blaser and MH Gail
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892-7368, USA.
An ELISA based on a pool of United States strains of Helicobacter pylori was compared with a newly developed ELISA based on a pool of Chinese strains. Both assays were tested using sera from 132 Chinese study subjects with biopsy-proven H. pylori infection. Using cutpoints designed to yield equal specificities of 94.9% in an uninfected control population, the sensitivity of the Chinese assay was 100.0%, compared to 97.7% for the United States assay (P = 0.25 by McNemar test). These results suggest that a H. pylori assay based on pooled antigens from United States strains will perform as well in the rural Chinese population as one based on antigens from Chinese strains.
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