Cancer Epidemiology Biomarkers & Prevention, Vol 6, Issue 11 967-969, Copyright © 1997 by American Association for Cancer Research

ARTICLES

Androgens in serum and the risk of prostate cancer: a nested case-control study from the Janus serum bank in Norway

LJ Vatten, G Ursin, RK Ross, FZ Stanczyk, RA Lobo, S Harvei and E Jellum
Department of Community Medicine and General Practice, University Medical Center, Trondheim, Norway. lars.vatten@medisin.ntnu.no

We tested the hypothesis that serum levels of testosterone (T), dihydrotestosterone (DHT), and the DHT metabolite 3 alpha,17 beta-androstanediol glucuronide are positively associated with the risk of prostate cancer. This nested case-control study was based on the cohort of men who donated blood to the Janus serum bank at Oslo University Hospital (Oslo, Norway) between 1973 and 1994. Cancer incidence was ascertained through linkage with the Norwegian Cancer Registry. The study included sera from 59 men who developed prostate cancer (cases) subsequent to blood donation and 180 men who were free of any diagnosed cancer (controls) in 1994 and were of similar age (+/- 1 year) and had similar blood storage time (+/- 6 months) to the cases. Neither T, DHT, nor the ratio T:DHT was associated with risk of developing prostate cancer. Compared to the bottom quartile, the odds ratio (OR) associated with the top quartile of T was 0.83 [95% confidence interval (CI), 0.36-1.93]; the OR for the top (compared to the bottom) quartile of DHT was 0.83 (95% CI, 0.36-1.94), and the equivalent OR for T:DHT was 1.31 (95% CI, 0.58-2.97). Similarly, 3 alpha,17 beta-androstanediol glucuronide showed no association with prostate cancer risk; the OR for the top (compared to the bottom) quartile was 1.10 (95% CI, 0.41-2.90). These results showed no association, positive or negative, between androgens measured in serum and the subsequent risk of developing prostate cancer.

This article has been cited by other articles:

				L. J. Vatten, J. M. Holly, D. Gunnell, and S. Tretli Nested Case-Control Study of the Association of Circulating Levels of Serum Insulin-like Growth Factor I and Insulin-like Growth Factor Binding Protein 3 with Breast Cancer in Young Women in Norway Cancer Epidemiol. Biomarkers Prev., August 1, 2008; 17(8): 2097 - 2100. [Abstract] [Full Text] [PDF]

				A. Hamada, T. Sissung, D. K. Price, R. Danesi, C. H. Chau, N. Sharifi, D. Venzon, K. Maeda, K. Nagao, A. Sparreboom, et al. Effect of SLCO1B3 Haplotype on Testosterone Transport and Clinical Outcome in Caucasian Patients with Androgen-Independent Prostatic Cancer Clin. Cancer Res., June 1, 2008; 14(11): 3312 - 3318. [Abstract] [Full Text] [PDF]

				E. Hormones and Prostate Cancer Collaborative Group Endogenous Sex Hormones and Prostate Cancer: A Collaborative Analysis of 18 Prospective Studies J Natl Cancer Inst, February 6, 2008; 100(3): 170 - 183. [Abstract] [Full Text] [PDF]

				C. Zeigler-Johnson, T. Friebel, A. H. Walker, Y. Wang, E. Spangler, S. Panossian, M. Patacsil, R. Aplenc, A. J. Wein, S. B. Malkowicz, et al. CYP3A4, CYP3A5, and CYP3A43 Genotypes and Haplotypes in the Etiology and Severity of Prostate Cancer Cancer Res., November 15, 2004; 64(22): 8461 - 8467. [Abstract] [Full Text] [PDF]

				C. Chen, N. S. Weiss, F. Z. Stanczyk, S. K. Lewis, D. DiTommaso, R. Etzioni, M. J. Barnett, and G. E. Goodman Endogenous Sex Hormones and Prostate Cancer Risk: A Case-Control Study Nested within the Carotene and Retinol Efficacy Trial Cancer Epidemiol. Biomarkers Prev., December 1, 2003; 12(12): 1410 - 1416. [Abstract] [Full Text] [PDF]

				C. Ntais, A. Polycarpou, and J. P. A. Ioannidis SRD5A2 Gene Polymorphisms and the Risk of Prostate Cancer: A Meta-Analysis Cancer Epidemiol. Biomarkers Prev., July 1, 2003; 12(7): 618 - 624. [Abstract] [Full Text] [PDF]

				S. Bhasin, A. B. Singh, R. P. Mac, B. Carter, M. I. Lee, and G. R. Cunningham Managing the Risks of Prostate Disease During Testosterone Replacement Therapy in Older Men: Recommendations for a Standardized Monitoring Plan J Androl, May 1, 2003; 24(3): 299 - 311. [Full Text] [PDF]

				C. Ntais, A. Polycarpou, and J. P. A. Ioannidis Association of the CYP17 Gene Polymorphism with the Risk of Prostate Cancer: A Meta-Analysis Cancer Epidemiol. Biomarkers Prev., February 1, 2003; 12(2): 120 - 126. [Abstract] [Full Text] [PDF]

				B. Cox, M. J. Sneyd, C. Paul, B. Delahunt, and D. C. G. Skegg Vasectomy and Risk of Prostate Cancer JAMA, June 19, 2002; 287(23): 3110 - 3115. [Abstract] [Full Text] [PDF]

				Z. Weihua, S. Makela, L. C. Andersson, S. Salmi, S. Saji, J. I. Webster, E. V. Jensen, S. Nilsson, M. Warner, and J.-A. Gustafsson A role for estrogen receptor beta in the regulation of growth of the ventral prostate PNAS, May 22, 2001; 98(11): 6330 - 6335. [Abstract] [Full Text] [PDF]

				A. H. Wu, A. S. Whittemore, L. N. Kolonel, F. Z. Stanczyk, E. M. John, R. P. Gallagher, and D. W. West Lifestyle Determinants of 5{{alpha}}-Reductase Metabolites in Older African-American, White, and Asian-American Men Cancer Epidemiol. Biomarkers Prev., May 1, 2001; 10(5): 533 - 538. [Abstract] [Full Text]

				C. Nagata, N. Takatsuka, H. Shimizu, H. Hayashi, T. Akamatsu, and K. Murase Effect of Soymilk Consumption on Serum Estrogen and Androgen Concentrations in Japanese Men Cancer Epidemiol. Biomarkers Prev., March 1, 2001; 10(3): 179 - 184. [Abstract] [Full Text]

				E. A. Platz, E. B. Rimm, W. C. Willett, P. W. Kantoff, and E. Giovannucci Racial Variation in Prostate Cancer Incidence and in Hormonal System Markers Among Male Health Professionals J Natl Cancer Inst, December 20, 2000; 92(24): 2009 - 2017. [Abstract] [Full Text] [PDF]

				M. C. Bosland Chapter 2: The Role of Steroid Hormones in Prostate Carcinogenesis J Natl Cancer Inst Monographs, July 1, 2000; 2000(27): 39 - 66. [Abstract] [Full Text] [PDF]

				M. Marcelli and G. R. Cunningham Hormonal Signaling in Prostatic Hyperplasia and Neoplasia J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3463 - 3468. [Full Text] [PDF]

				R. M. Lunn, D. A. Bell, J. L. Mohler, and J. A. Taylor Prostate cancer risk and polymorphism in 17 hydroxylase (CYP17) and steroid reductase (SRD5A2) Carcinogenesis, September 1, 1999; 20(9): 1727 - 1731. [Abstract] [Full Text] [PDF]