| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Cancer Epidemiology Biomarkers & Prevention, Vol 6, Issue 10 769-774, Copyright © 1997 by American Association for Cancer Research
ARTICLES |
E White, JS Shannon and RE Patterson
Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA.
The relationship between vitamin supplement use and colon cancer was assessed in a population-based case-control study among men and women aged 30-62 years. Cases were 251 men and 193 women diagnosed with colon cancer in 1985-1989 in three counties in the Seattle metropolitan area who were identified from the Surveillance, Epidemiology, and End Results cancer registry. Controls were 233 men and 194 women identified by random digit dialing. Supplement use was assessed by questions on frequency, duration, and dose per day (for individual supplements) or type (for multivitamins) during the 10-year period ending 2 years before diagnosis. All results were adjusted for age and sex and were not confounded by other measured behaviors. The average daily intake of supplemental vitamins A, C, E, folic acid, calcium, and multivitamins during the reference period were each associated with reduced risk of colon cancer (all P for trend < 0.03). The strongest associations were for use of vitamin E (odds ratio, 0.43; 95% confidence interval, 0.26-0.71 for > or = 200 IU/day versus none) and multivitamins (odds ratio, 0.49; 95% confidence interval, 0.35-0.69 for daily use versus no use; both P for trend < 0.001). These two associations were also significant using a stricter test of trend limited to supplement users, which reduces the effect of colinearity among these exposures. Because almost all vitamin D supplementation comes from multivitamin pills, the association of vitamin D use with colon cancer could not be distinguished from that of multivitamin use. Clinical trials or cohort studies with long-term assessment would be needed before public health recommendations could be made about supplement use.
This article has been cited by other articles:
|
|
 |
|
  S.-Y. Park, S. P. Murphy, L. R. Wilkens, A. M. Y. Nomura, B. E. Henderson, and L. N. Kolonel Calcium and Vitamin D Intake and Risk of Colorectal Cancer: The Multiethnic Cohort Study Am. J. Epidemiol., April 1, 2007; 165(7): 784 - 793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. V. Grau, J. A. Baron, R. S. Sandler, K. Wallace, R. W. Haile, T. R. Church, G. J. Beck, R. W. Summers, E. L. Barry, B. F. Cole, et al. Prolonged Effect of Calcium Supplementation on Risk of Colorectal Adenomas in a Randomized Trial J Natl Cancer Inst, January 17, 2007; 99(2): 129 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. G.K. Bentley, W. C. Willett, M. C. Weinstein, and K. M. Kuntz Population-Level Changes in Folate Intake by Age, Gender, and Race/Ethnicity after Folic Acid Fortification Am J Public Health, November 1, 2006; 96(11): 2040 - 2047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Zhang, S. C. Moore, J. Lin, N. R. Cook, J. E. Manson, I-M. Lee, and J. E. Buring Folate, Vitamin B6, Multivitamin Supplements, and Colorectal Cancer Risk in Women Am. J. Epidemiol., January 15, 2006; 163(2): 108 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Powers Interaction among Folate, Riboflavin, Genotype, and Cancer, with Reference to Colorectal and Cervical Cancer J. Nutr., December 1, 2005; 135(12): 2960S - 2966S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Hartman, P. S. Albert, K. Snyder, M. L. Slattery, B. Caan, E. Paskett, F. Iber, J. W. Kikendall, J. Marshall, M. Shike, et al. The Association of Calcium and Vitamin D with Risk of Colorectal Adenomas J. Nutr., February 1, 2005; 135(2): 252 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Peters, N. Chatterjee, K. A McGlynn, R. E Schoen, T. R Church, R. S Bresalier, M. M Gaudet, A. Flood, A. Schatzkin, and R. B Hayes Calcium intake and colorectal adenoma in a US colorectal cancer early detection program Am. J. Clinical Nutrition, November 1, 2004; 80(5): 1358 - 1365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. White, R. E. Patterson, A. R. Kristal, M. Thornquist, I. King, A. L. Shattuck, I. Evans, J. Satia-Abouta, A. J. Littman, and J. D. Potter VITamins And Lifestyle Cohort Study: Study Design and Characteristics of Supplement Users Am. J. Epidemiol., January 1, 2004; 159(1): 83 - 93. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Giovannucci, J. Chen, S. A. Smith-Warner, E. B. Rimm, C. S. Fuchs, C. Palomeque, W. C. Willett, and D. J. Hunter Methylenetetrahydrofolate Reductase, Alcohol Dehydrogenase, Diet, and Risk of Colorectal Adenomas Cancer Epidemiol. Biomarkers Prev., October 1, 2003; 12(10): 970 - 979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Jacobs, C. J. Connell, A. Chao, M. L. McCullough, C. Rodriguez, M. J. Thun, and E. E. Calle Multivitamin Use and Colorectal Cancer Incidence in a US Cohort: Does Timing Matter? Am. J. Epidemiol., October 1, 2003; 158(7): 621 - 628. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Boyapati, R. M. Bostick, K. A. McGlynn, M. F. Fina, W. M. Roufail, K. R. Geisinger, M. Wargovich, A. Coker, and J. R. Hebert Calcium, Vitamin D, and Risk for Colorectal Adenoma: Dependency on Vitamin D Receptor BsmI Polymorphism and Nonsteroidal Anti-Inflammatory Drug Use? Cancer Epidemiol. Biomarkers Prev., July 1, 2003; 12(7): 631 - 637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. B. Bailey, G. C. Rampersaud, and G. P. A. Kauwell Folic Acid Supplements and Fortification Affect the Risk for Neural Tube Defects, Vascular Disease and Cancer: Evolving Science, J. Nutr., June 1, 2003; 133(6): 1961S - 1968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Neuhouser Dietary Supplement Use by American Women: Challenges in Assessing Patterns of Use, Motives and Costs J. Nutr., June 1, 2003; 133(6): 1992S - 1996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Wu, W. C. Willett, J. M. Chan, C. S. Fuchs, G. A. Colditz, E. B. Rimm, and E. L. Giovannucci A Prospective Study on Supplemental Vitamin E Intake and Risk of Colon Cancer in Women and Men Cancer Epidemiol. Biomarkers Prev., November 1, 2002; 11(11): 1298 - 1304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Giovannucci Epidemiologic Studies of Folate and Colorectal Neoplasia: a Review J. Nutr., August 1, 2002; 132(8): 2350S - 2355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Fuchs, W. C. Willett, G. A. Colditz, D. J. Hunter, M. J. Stampfer, F. E. Speizer, and E. L. Giovannucci The Influence of Folate and Multivitamin Use on the Familial Risk of Colon Cancer in Women Cancer Epidemiol. Biomarkers Prev., March 1, 2002; 11(3): 227 - 234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. C. Willett and M. J. Stampfer What Vitamins Should I Be Taking, Doctor? N. Engl. J. Med., December 20, 2001; 345(25): 1819 - 1824. [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Shrubsole, F. Jin, Q. Dai, X.-O. Shu, J. D. Potter, J. R. Hebert, Y.-T. Gao, and W. Zheng Dietary Folate Intake and Breast Cancer Risk: Results from the Shanghai Breast Cancer Study Cancer Res., October 1, 2001; 61(19): 7136 - 7141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Kim, P. A. Newcomb, C. M. Ulrich, C. L. Keener, J. Bigler, F. M. Farin, R. M. Bostick, and J. D. Potter Vitamin D Receptor Polymorphism and the Risk of Colorectal Adenomas: Evidence of Interaction with Dietary Vitamin D and Calcium Cancer Epidemiol. Biomarkers Prev., August 1, 2001; 10(8): 869 - 874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Jacobs, C. J. Connell, A. V. Patel, A. Chao, C. Rodriguez, J. Seymour, M. L. McCullough, E. E. Calle, and M. J. Thun Vitamin C and Vitamin E Supplement Use and Colorectal Cancer Mortality in a Large American Cancer Society Cohort Cancer Epidemiol. Biomarkers Prev., January 1, 2001; 10(1): 17 - 23. [Abstract] [Full Text]
|
|
|
|
|
|
J. Song, A. Medline, J. B. Mason, S. Gallinger, and Y.-I. Kim Effects of Dietary Folate on Intestinal Tumorigenesis in the ApcMin Mouse Cancer Res., October 1, 2000; 60(19): 5434 - 5440. [Abstract] [Full Text]
|
|
|
|
 |
|
 W. C. Willett Diet and Cancer Oncologist, October 1, 2000; 5(5): 393 - 404. [Abstract] [Full Text]
|
|
|
|
|
|
R. L Wolf, J. A Cauley, C. E Baker, R. E Ferrell, M. Charron, A. W Caggiula, L. M Salamone, R. P Heaney, and L. H Kuller Factors associated with calcium absorption efficiency in pre- and perimenopausal women Am. J. Clinical Nutrition, August 1, 2000; 72(2): 466 - 471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Watkins, J. D. Erickson, M. J. Thun, J. Mulinare, and C. W. Heath Jr. Multivitamin Use and Mortality in a Large Prospective Study Am. J. Epidemiol., July 15, 2000; 152(2): 149 - 162. [Full Text] [PDF]
|
|
|
|
|
|
J. Song, K.-J. Sohn, A. Medline, C. Ash, S. Gallinger, and Y.-I. Kim Chemopreventive Effects of Dietary Folate on Intestinal Polyps in Apc+/- Msh2-/- Mice Cancer Res., June 1, 2000; 60(12): 3191 - 3199. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. Taniyama, H. Wanibuchi, E. I. Salim, Y. Yano, S. Otani, Y. Nishizawa, H. Morii, and S. Fukushima Chemopreventive effect of 24R,25-dihydroxyvitamin D3 in N,N'-dimethylhydrazine-induced rat colon carcinogenesis Carcinogenesis, February 1, 2000; 21(2): 173 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. R. Holt Dairy Foods and Prevention of Colon Cancer: Human Studies J. Am. Coll. Nutr., October 1, 1999; 18(90005): 379S - 391. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
