Cancer Epidemiology Biomarkers & Prevention, Vol 5, Issue 12 997-1003, Copyright © 1996 by American Association for Cancer Research

ARTICLES

p53 mutations and occupational exposures in a surgical series of lung cancers

LC Harty, DG Guinee Jr, WD Travis, WP Bennett, J Jett, TV Colby, H Tazelaar, V Trastek, P Pairolero, LA Liotta, CC Harris and NE Caporaso
Genetic Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

p53 mutations are frequent in malignant lung tumors. Of 88 surgically treated lung cancers from cigarette smokers previously evaluated for p53 mutations, 45 tumors (51.1%) had mutations in exons 5-8 (D. G. Guinee, Jr. et al., Carcinogenesis (Lond.), 16: 993-1002, 1995). We report here the examination of 13 occupational exposures and 13 high-risk occupations in relation to these p53 mutations. Two molecular abnormalities were associated with occupational exposures: (a) G:C-->T:A transversions on the coding (nontranscribed) strand (n = 13) were associated with chromate exposure and employment in the metal industry (P < 0.05) and marginally associated with nickel exposure (P = 0.056); and (b) G:C-->A:T transitions at non-CpG sites (n = 9) were associated with work in the petrochemical industry (P = 0.05). No association was found between p53 mutations and gender, cigarette pack-years, tumor histology, age at diagnosis, or family history of lung cancer. Because all three chromate-exposed subjects had large cell carcinomas exhibiting G: C-->T:A coding-strand transversions, follow-up of a cohort with this exposure should clarify the association with the p53 gene.

This article has been cited by other articles:

				H. Arakawa, F. Wu, M. Costa, W. Rom, and M.-s. Tang Sequence specificity of Cr(III)-DNA adduct formation in the p53 gene: NGG sequences are preferential adduct-forming sites Carcinogenesis, March 1, 2006; 27(3): 639 - 645. [Abstract] [Full Text] [PDF]

				Z. Feng, W. Hu, W. N. Rom, M. Costa, and M.-S. Tang Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cells Carcinogenesis, April 1, 2003; 24(4): 771 - 778. [Abstract] [Full Text] [PDF]

				K. Husgafvel-Pursiainen, A. Karjalainen, A. Kannio, S. Anttila, T. Partanen, A. Ojajärvi, and H. Vainio Lung Cancer and Past Occupational Exposure to Asbestos . Role of p53 and K-ras Mutations Am. J. Respir. Cell Mol. Biol., April 1, 1999; 20(4): 667 - 674. [Abstract] [Full Text]