Cancer Epidemiology Biomarkers & Prevention, Vol 4, Issue 4 367-372, Copyright © 1995 by American Association for Cancer Research

ARTICLES

Altered expression of class I HLA antigen on peripheral mononuclear cells in patients with adult T-cell leukemia: inverse relationship with natural killer susceptibility

H Uno, H Matsuoka, M Suzuki, K Tsuda and H Tsubouchi
Second Department of Internal Medicine, Miyazaki Medical School, Japan.

Patients with adult T-cell leukemia showed altered expression of class I HLA antigen in their peripheral blood lymphocytes. Acute type adult T-cell leukemia showed increased levels of the antigen expression compared to those of control group and smoldering type (P < 0.001 and 0.01, respectively). Natural killer sensitivity of infected cell lines with different levels of class I HLA expression showed an inverse relationship with the antigen expression. Further, various cell lines including human T-cell leukemia virus type I-infected cell lines treated with acid buffer, which selectively eliminated the surface class I HLA molecules from cell membrane, became more sensitive to natural killer-mediated lysis. These data suggested that the enhanced expression of class I HLA on peripheral blood lymphocytes of patients with acute type adult T-cell leukemia may contribute to escaping from the immunosurveillance system of natural killer cells in vivo.

This article has been cited by other articles:

				P. Banerjee, G. Feuer, and E. Barker Human T-Cell Leukemia Virus Type 1 (HTLV-1) p12I Down-Modulates ICAM-1 and -2 and Reduces Adherence of Natural Killer Cells, Thereby Protecting HTLV-1-Infected Primary CD4+ T Cells from Autologous Natural Killer Cell-Mediated Cytotoxicity despite the Reduction of Major Histocompatibility Complex Class I Molecules on Infected Cells J. Virol., September 15, 2007; 81(18): 9707 - 9717. [Abstract] [Full Text] [PDF]

				T. Ohashi, S. Hanabuchi, R. Suzuki, H. Kato, T. Masuda, and M. Kannagi Correlation of Major Histocompatibility Complex Class I Downregulation with Resistance of Human T-Cell Leukemia Virus Type 1-Infected T Cells to Cytotoxic T-Lymphocyte Killing in a Rat Model J. Virol., June 14, 2002; 76(14): 7010 - 7019. [Abstract] [Full Text] [PDF]

				J. M. Johnson, C. Nicot, J. Fullen, V. Ciminale, L. Casareto, J. C. Mulloy, S. Jacobson, and G. Franchini Free Major Histocompatibility Complex Class I Heavy Chain Is Preferentially Targeted for Degradation by Human T-Cell Leukemia/Lymphotropic Virus Type 1 p12I Protein J. Virol., July 1, 2001; 75(13): 6086 - 6094. [Abstract] [Full Text] [PDF]

				J. E. K. Hildreth Syncytium-Inhibiting Monoclonal Antibodies Produced against Human T-Cell Lymphotropic Virus Type 1-Infected Cells Recognize Class II Major Histocompatibility Complex Molecules and Block by Protein Crowding J. Virol., December 1, 1998; 72(12): 9544 - 9552. [Abstract] [Full Text] [PDF]