Cancer Epidemiology Biomarkers & Prevention, Vol 2, Issue 6 525-530, Copyright © 1993 by American Association for Cancer Research

ARTICLES

A case control study of nutritional factors and cervical dysplasia

T Liu, SJ Soong, NP Wilson, CB Craig, P Cole, M Macaluso and CE Butterworth Jr
Biostatistics Unit, University of Alabama at Birmingham 35294.

The association of nutritional factors with cervical dysplasia was examined through a case-control study. Analysis was conducted in 257 cases and 133 controls confirmed both by cytological examination and colposcopic findings. A 24-h dietary recall questionnaire was used to assess nutritional intake. Various risk factors (including age at first intercourse, number of sexual partners, parity, cigarette smoking, oral contraceptive use, human papillomavirus type 16 infection, and age and race) were adjusted for their potential confounding effects. While analyses were also performed to adjust for total calories, results were not changed significantly. Among the nutrients examined, vitamin A intake showed a significantly increased risk at the lowest quartile compared to the highest quartile, with an odds ratio of 2.2 (95% confidence interval, 1.2-4.2). A significant trend of increasing risk was also observed with lower intake of vitamin A (P = 0.05). Riboflavin showed increased risk at the two lower quartiles of intake with a trend test P value of 0.04. Increased risk was also found for lower intakes of vitamin C compared to the highest intake level. For folate, increased risk was found in the second highest quartile compared with the highest quartile with an odds ratio of 2.0 (95% confidence interval, 1.0-3.8). The calcium:phosphorus ratio showed an increased risk at the lowest level (odds ratio, 2.0; 95% confidence interval, 1.0-4.3). Insufficient intake of vitamin A, riboflavin, ascorbate, and folate is associated with an increased risk of cervical dysplasia.

This article has been cited by other articles:

				B. C Tohill, C. M Heilig, R. S Klein, A. Rompalo, S. Cu-Uvin, E. G Piwoz, D. J Jamieson, and A. Duerr Nutritional biomarkers associated with gynecological conditions among US women with or at risk of HIV infection Am. J. Clinical Nutrition, May 1, 2007; 85(5): 1327 - 1334. [Abstract] [Full Text] [PDF]

				H. J. Powers Interaction among Folate, Riboflavin, Genotype, and Cancer, with Reference to Colorectal and Cervical Cancer J. Nutr., December 1, 2005; 135(12): 2960S - 2966S. [Abstract] [Full Text] [PDF]

				H. J Powers Riboflavin (vitamin B-2) and health Am. J. Clinical Nutrition, June 1, 2003; 77(6): 1352 - 1360. [Abstract] [Full Text] [PDF]

				R. L. Sedjo, D. J. Roe, M. Abrahamsen, R. B. Harris, N. Craft, S. Baldwin, and A. R. Giuliano Vitamin A, Carotenoids, and Risk of Persistent Oncogenic Human Papillomavirus Infection Cancer Epidemiol. Biomarkers Prev., September 1, 2002; 11(9): 876 - 884. [Abstract] [Full Text] [PDF]

				R. L. Sedjo, P. Inserra, M. Abrahamsen, R. B. Harris, D. J. Roe, S. Baldwin, and A. R. Giuliano Human Papillomavirus Persistence and Nutrients Involved in the Methylation Pathway among a Cohort of Young Women Cancer Epidemiol. Biomarkers Prev., April 1, 2002; 11(4): 353 - 359. [Abstract] [Full Text] [PDF]

				M. Benchalal, E. Yahchouchy-Chouillard, S. Fouere, and A. Fingerhut Anaphylactic shock secondary to intravenous administration of folinic acid: a first report Ann. Onc., March 1, 2002; 13(3): 480 - 481. [Abstract] [Full Text] [PDF]

				M. T. Goodman, K. McDuffie, B. Hernandez, L. R. Wilkens, C. C. Bertram, J. Killeen, L. Le Marchand, J. Selhub, S. Murphy, and T. A. Donlon Association of Methylenetetrahydrofolate Reductase Polymorphism C677T and Dietary Folate with the Risk of Cervical Dysplasia Cancer Epidemiol. Biomarkers Prev., December 1, 2001; 10(12): 1275 - 1280. [Abstract] [Full Text] [PDF]

				S. J. Weinstein, R. G. Ziegler, E. A. Frongillo Jr., N. Colman, H. E. Sauberlich, L. A. Brinton, R. F. Hamman, R. S. Levine, K. Mallin, P. D. Stolley, et al. Low Serum and Red Blood Cell Folate Are Moderately, but Nonsignificantly Associated with Increased Risk of Invasive Cervical Cancer in U.S. Women J. Nutr., July 1, 2001; 131(7): 2040 - 2048. [Abstract] [Full Text] [PDF]

				A. J. Alberg, J. Selhub, K. V. Shah, R. P. Viscidi, G. W. Comstock, and K. J. Helzlsouer The Risk of Cervical Cancer in Relation to Serum Concentrations of Folate, Vitamin B12, and Homocysteine Cancer Epidemiol. Biomarkers Prev., July 1, 2000; 9(7): 761 - 764. [Abstract] [Full Text]