Cancer Epidemiology Biomarkers & Prevention, Vol 2, Issue 4 397-399, Copyright © 1993 by American Association for Cancer Research

ARTICLES

Familial Barrett esophagus and adenocarcinoma of the gastroesophageal junction [published erratum appears in Cancer Epidemiol Biomarkers Prev 1993 Sep-Oct;2(5):505]

C Eng, SJ Spechler, R Ruben and FP Li
CRC Human Cancer Genetics Research Group, University of Cambridge, United Kingdom.

Barrett esophagus was found in seven members of a single family. Two of these patients also had adenocarcinoma of the gastroesophageal junction. Among family members who did not have Barrett epithelium, one had esophageal ulcerations with dysplasia in squamous epithelium and another had an esophageal stricture. The pattern of involvement suggests autosomal dominant inheritance of Barrett esophagus and/or gastroesophageal reflux disease in this family, with a strong predisposition for adenocarcinoma of the esophagus.

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