This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Schmitz, K. H. Articles by Kurzer, M. S. Search for Related Content PubMed PubMed Citation Articles by Schmitz, K. H. Articles by Kurzer, M. S. Related Collections Clinical Intervention Clinical Intervention: Biomarkers

Exercise Effect on Oxidative Stress Is Independent of Change in Estrogen Metabolism

¹ Division of Epidemiology, University of Minnesota School of Public Health; ² Department of Lab Pathology, University of Minnesota School of Medicine, Minneapolis, Minnesota; ³ Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; ⁴ Department of Physical Therapy, Northern Arizona University, Flagstaff, Arizona; ⁵ Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York; ⁶ Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania; and ⁷ Department of Food Science and Nutrition, University of Minnesota, St. Paul, Minnesota

Requests for reprints: Kathryn H. Schmitz, Division of Clinical Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 921 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104. Phone: 215-898-6604; Fax: 215-573-2265. E-mail: schmitz{at}mail.med.upenn.edu

Purpose: The effect of exercise training on lipid peroxidation and endogenous estrogens is not well understood in premenopausal women. Exercise effects on these variables could mediate observed associations of exercise with hormonally related cancers, including breast cancer. The purpose of the study is to determine the effect of 15 weeks of aerobic exercise on lipid peroxidation, endogenous estrogens, and body composition in young, healthy eumenorrheic women.

Methods: Fifteen sedentary premenopausal women (18-25 years) participated. Pre- and post-exercise training urine collection (three 24-h samples) started 48 h after most recent exercise session for analysis of a marker of lipid peroxidation (F₂-isoprostane) and endogenous estrogens, including 2-hydroxyestrogens, 4-hydroxyestrogens, 16--hydroxyestrone, and ratios of these metabolites (2:16, 2:4). Body composition was measured by dual-energy X-ray absorptiometry, and F₂-isoprostanes and estrogens were measured by gas chromatography-mass spectrometry.

Results: Aerobic exercise resulted in a 34% decrease in F₂-isoprostane (P = 0.02), a 10% increase in fitness (P = 0.004), a 1.2 kg decrease in body mass (P = 0.007), and a 1.8 kg decrease in fat mass (P = 0.04). No significant changes were noted in estrogens.

Conclusions: The effect of exercise training on oxidative stress may be relevant to risk for hormonally related cancers. (Cancer Epidemiol Biomarkers Prev 2008;17(1):220–3)