This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Malmer, B. Articles by Bondy, M. Search for Related Content PubMed PubMed Citation Articles by Malmer, B. Articles by Bondy, M.

GLIOGENE—an International Consortium to Understand Familial Glioma

¹ Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden; ² Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center; ³ Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas; ⁴ Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio; ⁵ Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center; ⁶ Brain Tumor Center, Neurological Institute, Columbia University, New York, New York; ⁷ Department of Epidemiology and Public Health, Yale University, New Haven, Connecticut; ⁸ Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts; ⁹ Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, Illinois; ¹⁰ Institute of Cancer Research, Surrey, United Kingdom; ¹¹ Department of Community and Family Medicine and the Duke Comprehensive Cancer Center, Durham, North Carolina; ¹² Department of Laboratory Medicine and Pathology, Mayo Clinic; ¹³ Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, Minnesota; ¹⁴ Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark; ¹⁵ Cancer and Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; ¹⁶ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; and ¹⁷ Department of Neurological Surgery, University of California at San Francisco, San Francisco, California

Requests for reprints: Melissa Bondy, Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Unit 1340, P.O. Box 301439, Houston, TX 77230-1439. Phone: 713-794-5264; Fax: 713-792-9568. E-mail: mbondy{at}mdanderson.org or Beatrice Malmer, Department of Radiation Sciences, Oncology, Umeå University, 901 85 Umeå, Sweden. Phone: 46-730918028; Fax: 46-907852031. E-mail: Beatrice.malmer{at}onkologi.umu.se

Evidence for familial aggregation of glioma has been documented in both case-control and cohort studies and occurs apart from the well-described rare inherited genetic syndromes involving glioma: neurofibromatosis type 1 and 2, tuberous sclerosis, Turcot's syndrome, and Li-Fraumeni syndrome. Nonsyndromic glioma families have been studied but no genes have been identified in the two published linkage studies of familial glioma probably due to the small number of families. Because glioma is a rare but devastating cancer, and a family history of glioma has been observed in 5% of the cases, we initiated an international consortium to identify glioma families not affected by syndromes to better understand the inherited factors related to this disease. The international consortium GLIOGENE is an acronym for "glioma gene" and includes 15 research groups in North America, Europe, and Israel to study familial glioma. The overarching goal is to characterize genes in glioma families using a genome-wide single-nucleotide polymorphism approach and conducting linkage analysis to identify new genomic regions or loci that could harbor genes important for gliomagenesis. Here, we review the rationale for studying familial glioma and our proposed strategy for the GLIOGENE study. (Cancer Epidemiol Biomarkers Prev 2007;16(9):1730–4)

This article has been cited by other articles:

				P. Y. Wen and S. Kesari Malignant Gliomas in Adults N. Engl. J. Med., July 31, 2008; 359(5): 492 - 507. [Full Text] [PDF]

				F. G. Davis, B. S. Malmer, K. Aldape, J. S. Barnholtz-Sloan, M. L. Bondy, T. Brannstrom, J. M. Bruner, P. C. Burger, V. P. Collins, P. D. Inskip, et al. Issues of Diagnostic Review in Brain Tumor Studies: From the Brain Tumor Epidemiology Consortium Cancer Epidemiol. Biomarkers Prev., March 1, 2008; 17(3): 484 - 489. [Abstract] [Full Text] [PDF]