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A Method of Producing Carcinoma in Upper Aerodigestive Tree and Esophagus of the Syrian Golden Hamster Using Wounding and Instillation of N-Methylnitrosourea

Departments of ¹ Laboratory Medicine and Pathology and ² Otolaryngology, University of Minnesota School of Medicine, Minneapolis, Minnesota

Requests for reprints: Richard Estensen, 220 Lions Research Building, 2001 6th Street Southeast, Minneapolis, MN 55455. Phone: 715-349-7198; Fax: 612-626-9198. E-mail: esten001{at}umn.edu

Details of a method for producing carcinoma of the aerodigestive tree of the Syrian golden hamster and the use of this model to evaluate putative agents for chemoprevention of these carcinomas are described. The method produces a majority of squamous carcinomas of the trachea and glottis that follow squamous metaplasia of respiratory epithelium. In addition, seen are adenocarcinomas arising in glands of the respiratory tree. Squamous carcinomas of the digestive epithelium arise in primary squamous epithelium. These tumors of digestive epithelium have a growth pattern that differs from that of the respiratory epithelium in that they grow and invade without filling the epithelial layer with tumor cells.(Cancer Epidemiol Biomarkers Prev 2007;16(8):1644–50) (Cancer Epidemiol Biomarkers Prev 2007;16(8):1644–50)