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Cholecystectomy and the Risk of Recurrent Colorectal Adenomas

¹ Department of Epidemiology, School of Public Health, and Center for Gastrointestinal Biology and Disease; ² Department of Medicine and Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, North Carolina; ³ Section of Gastroenterology, VA Medical Center, White River Junction, Vermont; ⁴ Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire; and ⁵ Departments of Medicine and Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire; and ⁶ Division of Gastroenterology-Hepatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa

Requests for reprints: Lisa C. Vinikoor, Center for Gastrointestinal Biology and Disease, CB#7555, University of North Carolina, Chapel Hill, NC 27599-7555. Phone: 919-843-0758; Fax: 919-966-9185. E-mail: vinikoor{at}email.unc.edu

Prior studies have shown an increased risk of colorectal cancer following cholecystectomy, but few studies have explored the association between cholecystectomy and the risk of colorectal adenomas. We used data from three large randomized adenoma chemoprevention trials to explore the association between cholecystectomy and the occurrence of adenomas. After adjusting for confounding factors, we found no increased risk for adenomas among individuals who had undergone cholecystectomy [risk ratio (RR), 1.02; 95% confidence interval (95% CI), 0.88-1.18]. There was a slight increase in the risk of advanced recurrent adenomas (RR, 1.28; 95% CI, 0.94-1.76) and multiple advanced recurrent adenomas (RR, 1.34; 95% CI, 0.97-1.85) but the 95% CIs included the null in both cases. We conclude that the increased risk for colorectal cancer following cholecystectomy seems to be due to a biological process occurring after the adenoma has developed. (Cancer Epidemiol Biomarkers Prev 2007;16(7):1523–5)