This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kopelovich, L. Articles by Crowell, J. A. Search for Related Content PubMed PubMed Citation Articles by Kopelovich, L. Articles by Crowell, J. A. Related Collections Review Epidemiology and Prevention Epidemiology and Prevention: Chemoprevention

The Mammalian Target of Rapamycin Pathway as a Potential Target for Cancer Chemoprevention

¹ Division of Cancer Prevention, National Cancer Institute, NIH, Bethesda, Maryland and ² CCS Associates, Mountain View, California

Requests for reprints: Levy Kopelovich, National Institutes of Health, National Cancer Institute, Division of Cancer Prevention, Chemopreventive Agent Development Research Group, 6130 Executive Blvd. Bethesda, MD 20892. Phone: 301-94-0467; Fax: 301-402-0553. E-mail: lk94c{at}nih.gov

The mammalian target of rapamycin (mTOR) is a key signaling node coordinating cell cycle progression and cell growth in response to genetic, epigenetic, and environmental conditions. Pathways involved in mTOR signaling are dysregulated in precancerous human tissues. These findings, together with the intriguing possibility that mTOR suppression may be associated with antitumor actions of caloric restriction, suggest that mTOR signaling may be an important target for chemopreventive drugs. (Cancer Epidemiol Biomarkers Prev 2007;16(7):1330–40)

This article has been cited by other articles:

				J. R. Fay, V. Steele, and J. A. Crowell Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase Cancer Prevention Research, April 1, 2009; 2(4): 301 - 309. [Abstract] [Full Text] [PDF]

				K.-K. Wong Oral-Specific Chemical Carcinogenesis in Mice: An Exciting Model for Cancer Prevention and Therapy Cancer Prevention Research, January 1, 2009; 2(1): 10 - 13. [Full Text] [PDF]

				K. Singletary and J. Milner Diet, Autophagy, and Cancer: A Review Cancer Epidemiol. Biomarkers Prev., July 1, 2008; 17(7): 1596 - 1610. [Abstract] [Full Text] [PDF]

				N. Yeager, C. Brewer, K. Q. Cai, X.-X. Xu, and A. Di Cristofano Mammalian Target of Rapamycin Is the Key Effector of Phosphatidylinositol-3-OH Initiated Proliferative Signals in the Thyroid Follicular Epithelium Cancer Res., January 15, 2008; 68(2): 444 - 449. [Abstract] [Full Text] [PDF]

				G. C. Prendergast Recent Movement to Exploit Key Signaling Molecules and Cancer Vaccines Cancer Reviews Online Content, August 1, 2007; 2007(5): 9 - 9. [Full Text] [PDF]