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Is TGFBR1*6A a Susceptibility Allele for Nonsyndromic Familial Colorectal Neoplasia?

Departments of ¹ Epidemiology and Biostatistics, ² Genetics, ³ Pathology and ⁴ Medicine, ⁵ Case Comprehensive Cancer Center, ⁶ Center for Human Genetics, ⁷ University Hospitals of Cleveland/Case Western Reserve University and Howard Hughes Medical Institute, and Cleveland, Ohio and the ⁸ University of British Columbia, Vancouver, BC, Canada

Requests for reprints: Denise Daley, 166 Burrard Building, 1081 Burrard Street, Vancouver, BC, Canada V6Z1Y6. Phone: 604-682-2344; Fax: 604-806-8351. E-mail: ddaley{at}mrl.ubc.ca

Our analysis definitely excludes the possibility of the TGFBR1*6A allele increasing the risk of colorectal neoplasia in our sample population. A recent study validating linkage of colorectal cancer to chromosome 9q also excluded the TGFBR1*6A allele as a disease-causing variant in that sample. We conclude that there remains an unidentified susceptibility locus in the region 9q22.2-31.2. (Cancer Epidemiol Biomarkers Prev 2007;16(5):892–4)