This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Suuriniemi, M. Articles by Ostrander, E. A. Search for Related Content PubMed PubMed Citation Articles by Suuriniemi, M. Articles by Ostrander, E. A.

Confirmation of a Positive Association between Prostate Cancer Risk and a Locus at Chromosome 8q24

¹ Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland; ² Fred Hutchinson Cancer Research Center, Divisions of Public Health Sciences; ³ Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington; and ⁴ Division of Biostatistics, Mayo Clinic, Rochester, Minnesota

Requests for reprints: Elaine A. Ostrander, Cancer Genetics Branch, National Human Genome Research Institute, NIH, 50 South Drive, Room 5351, Bethesda, MD 20892. Phone: 301-594-5284; Fax: 301-480-0472. E-mail: eostrand{at}mail.nih.gov

Background: Family-based linkage studies, association studies, and studies of tumors have highlighted human chromosome 8q as a genomic region of interest for prostate cancer susceptibility loci. Recently, a locus at 8q24, characterized by both a single nucleotide polymorphism (SNP) and a microsatellite marker, was shown to be associated with prostate cancer risk in Icelandic, Swedish, and U.S. samples. Although the data were provocative, the U.S. samples were not population based, which precludes assessment of the potential contribution of this locus to prostate cancer incidence in the United States.

Methods: We analyzed both markers in a population-based, case-control study of middle-aged men from King County, Washington.

Results: Overall, there was a significant positive association between the A allele of the SNP rs1447295 and prostate cancer risk [odds ratio, 1.4; 95% confidence interval (95% CI), 1.1-2.0] but no significant association with the microsatellite DG8S737. However, significant associations were observed for both markers in men with high Gleason scores. Adjusting for age, first-degree family history of prostate cancer, and prostate cancer screening history, the adjusted odds ratios were 1.4 (95% CI, 1.1-1.8) for the A allele of the SNP and 1.9 (95% CI, 1.2-2.8) for the –10 allele of the microsatellite.

Conclusions: These data suggest that the locus on chromosome 8q24 harbors a genetic variant associated with prostate cancer and that the microsatellite marker is a stronger risk factor for aggressive prostate cancers defined by poorly differentiated tumor morphology. (Cancer Epidemiol Biomarkers Prev 2007;16(4):809–14)

This article has been cited by other articles:

				C. A. Salinas, E. Kwon, C. S. Carlson, J. S. Koopmeiners, Z. Feng, D. M. Karyadi, E. A. Ostrander, and J. L. Stanford Multiple Independent Genetic Variants in the 8q24 Region Are Associated with Prostate Cancer Risk Cancer Epidemiol. Biomarkers Prev., May 1, 2008; 17(5): 1203 - 1213. [Abstract] [Full Text] [PDF]

				S. L. Zheng, J. Sun, F. Wiklund, S. Smith, P. Stattin, G. Li, H.-O. Adami, F.-C. Hsu, Y. Zhu, K. Balter, et al. Cumulative Association of Five Genetic Variants with Prostate Cancer N. Engl. J. Med., February 28, 2008; 358(9): 910 - 919. [Abstract] [Full Text] [PDF]

				C. Robbins, J. B. Torres, S. Hooker, C. Bonilla, W. Hernandez, A. Candreva, C. Ahaghotu, R. Kittles, and J. Carpten Confirmation study of prostate cancer risk variants at 8q24 in African Americans identifies a novel risk locus Genome Res., December 1, 2007; 17(12): 1717 - 1722. [Abstract] [Full Text] [PDF]

				S. A. Savage and M. H. Greene The Evidence for Prostate Cancer Risk Loci at 8q24 Grows Stronger J Natl Cancer Inst, October 17, 2007; 99(20): 1499 - 1501. [Full Text] [PDF]

				P. Vineis and F. Perera Molecular Epidemiology and Biomarkers in Etiologic Cancer Research: The New in Light of the Old Cancer Epidemiol. Biomarkers Prev., October 1, 2007; 16(10): 1954 - 1965. [Abstract] [Full Text] [PDF]