| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
1 Public Health Sciences and 2 Colon Cancer Genetics Group, Western General Hospital, University of Edinburgh; 3 South East Scotland Genetic Service, Edinburgh, United Kingdom; and 4 Environmental and Occupational Medicine Department, Liberty Safe Work Research Centre, University of Aberdeen, Aberdeen, United Kingdom
Requests for reprints: Evropi Theodoratou, Public Health Sciences, College of Medicine and Vet Medicine, University of Edinburgh, Edinburgh, United Kingdom. Phone: 44-131-650-3036; Fax: 44-131-650-6909. E-mail: E.Theodoratou{at}sms.ed.ac.uk
In vitro and in vivo laboratory data point to chemoprotective effects of flavonoids on colorectal cancer. However, there has been limited epidemiologic research on the dietary intake of flavonoids and risk of colorectal cancer. Recent expansions of dietary databases to include flavonoid data now make such studies feasible. Association between the six main classes of flavonoids and the risk of colorectal cancer was examined using data from a national prospective case-control study in Scotland, including 1,456 incident cases and 1,456 population-based controls matched on age, sex, and residence area. Dietary, including flavonoid data, were obtained from a validated, self-administered food frequency questionnaire. Risk of colorectal cancer was estimated using conditional logistic regression models in the whole sample and stratified by sex, smoking status, and cancer site and adjusted for established and putative risk factors. After energy adjustment, reductions in colorectal cancer risk associated with the highest quartiles of intake (versus the lowest quartile) were 27% for flavonols [odds ratio (OR), 0.73; Ptrend = 0.012], 32% for quercetin (OR, 0.68; Ptrend = 0.001), 32% for catechin (OR, 0.68; Ptrend < 0.0005); 26% for epicatechin (OR, 0.74; Ptrend = 0.019), and 22% for procyanidins (OR, 0.78; Ptrend = 0.031). The significant dose-dependent reductions in colorectal cancer risk that were associated with increased consumption of flavonols, quercetin, catechin, and epicatechin remained robust after controlling for overall fruit and vegetable consumption or for other flavonoid intake. The risk reductions were greater among nonsmokers, but no interaction beyond a multiplicative effect was present. Sex-specific or cancer-type differences were not observed. No risk reductions were associated with intake of flavones (Ptrend = 0.64), flavonones (Ptrend = 0.22), and phytoestrogens (Ptrend = 0.26). This was the first of several a priori hypotheses to be tested in this large study and showed strong and linear inverse associations of flavonoids with colorectal cancer risk. (Cancer Epidemiol Biomarkers Prev 2007;16(4):684–93)
This article has been cited by other articles:
|
|
 |
|
  Q. Zhou, B. Yan, X. Hu, X.-B. Li, J. Zhang, and J. Fang Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin Mol. Cancer Ther., June 1, 2009; 8(6): 1684 - 1691. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wang, I-M. Lee, S. M Zhang, J. B Blumberg, J. E Buring, and H. D Sesso Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older women Am. J. Clinical Nutrition, March 1, 2009; 89(3): 905 - 912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Nothlings, S. P Murphy, L. R Wilkens, H. Boeing, M. B Schulze, H B. Bueno-de-Mesquita, D. S Michaud, A. Roddam, S. Rohrmann, A. Tjonneland, et al. A food pattern that is predictive of flavonol intake and risk of pancreatic cancer Am. J. Clinical Nutrition, December 1, 2008; 88(6): 1653 - 1662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lamy, V. Bedard, D. Labbe, H. Sartelet, C. Barthomeuf, D. Gingras, and R. Beliveau The Dietary Flavones Apigenin and Luteolin Impair Smooth Muscle Cell Migration and VEGF Expression through Inhibition of PDGFR-{beta} Phosphorylation Cancer Prevention Research, November 1, 2008; 1(6): 452 - 459. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Theodoratou, H. Campbell, A. Tenesa, G. McNeill, R. Cetnarskyj, R. A. Barnetson, M. E. Porteous, M. G. Dunlop, and S. M. Farrington Modification of the associations between lifestyle, dietary factors and colorectal cancer risk by APC variants Carcinogenesis, September 1, 2008; 29(9): 1774 - 1780. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Bobe, L. B. Sansbury, P. S. Albert, A. J. Cross, L. Kahle, J. Ashby, M. L. Slattery, B. Caan, E. Paskett, F. Iber, et al. Dietary Flavonoids and Colorectal Adenoma Recurrence in the Polyp Prevention Trial Cancer Epidemiol. Biomarkers Prev., June 1, 2008; 17(6): 1344 - 1353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Theodoratou, S. M. Farrington, A. Tenesa, G. McNeill, R. Cetnarskyj, R. A. Barnetson, M. E. Porteous, M. G. Dunlop, and H. Campbell Dietary Vitamin B6 Intake and the Risk of Colorectal Cancer Cancer Epidemiol. Biomarkers Prev., January 1, 2008; 17(1): 171 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Theodoratou, G. McNeill, R. Cetnarskyj, S. M. Farrington, A. Tenesa, R. Barnetson, M. Porteous, M. Dunlop, and H. Campbell Dietary Fatty Acids and Colorectal Cancer: A Case-Control Study Am. J. Epidemiol., July 15, 2007; 166(2): 181 - 195. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
