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Phenol Sulfotransferase SULT1A1*2 Allele and Enhanced Risk of Upper Urinary Tract Urothelial Cell Carcinoma

¹ Institute for Cancer Studies and Academic Urology Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, United Kingdom; ² CeRePP Group, EA3104, University Paris VII; ³ Assistance Publique-Hôpitaux de Paris, Department of Urology and Department of Pathology, Pitié-Tenon Hospital, GHU Est, University Paris VI; ⁴ Pathology Department, Saint-Joseph Hospital, Paris, France; ⁵ CHU La Miletrie, Pathology Department, University of Poitiers, Poitiers, France; ⁶ Institut National de la Santé et de la Recherche Médicale EMI0337, University Paris XII, Créteil, France; ⁷ CHU Angers, Department of Pathology, University of Angers, Angers, France; and ⁸ CHU Nancy-Brabois, Department of Urology and Department of Pathology, University of Nancy, Nancy, France

Requests for reprints: Morgan Rouprêt, Royal Hallamshire Hospital, Institute for Cancer Studies, Academic Urology Unit, K Floor, Glossop Road, S10 2JF Sheffield, United Kingdom. Phone: 44-114-271-1648; Fax: 44-114-271-2268; E-mail: morgan.roupret{at}psl.aphp.fr

Cytosolic sulfotransferases (SULT) are involved in detoxification pathways. A functional polymorphism in the SULT1A1 gene, leading to an Arg213His substitution (SULT1A1*2), is thought to confer susceptibility to various types of cancer. Upper urinary tract urothelial cell carcinomas (UUT-UCC) are rare (5% of all urothelial carcinomas). We genotyped 268 patients with UUT-UCC and 268 healthy controls matched for age, gender, tobacco consumption, and ethnicity. His213 (SULT1A1*2) allele frequency was significantly higher in patients than in controls (37.1% versus 28.9%; P = 0.004). The His/His genotype corresponding to low-activity SULT1A1 enzyme conferred a significantly higher risk of UUT-UCC (odds ratio, 2.18; 95% confidence interval, 1.28-3.69; P = 0.004).(Cancer Epidemiol Biomarkers Prev 2007;16(11):1–4) (Cancer Epidemiol Biomarkers Prev 2007;16(11):2500–3)