This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schwartzbaum, J. A. Articles by Feychting, M. Search for Related Content PubMed PubMed Citation Articles by Schwartzbaum, J. A. Articles by Feychting, M.

An International Case-Control Study of Interleukin-4R, Interleukin-13, and Cyclooxygenase-2 Polymorphisms and Glioblastoma Risk

¹ Division of Epidemiology, School of Public Health and ² Comprehensive Cancer Center, Ohio State University, Columbus, Ohio; ³ Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; ⁴ Department of Radiation Sciences, Oncology, Umeå University Hospital, Umeå, Sweden; ⁵ Departments of Epidemiology, Tampere School of Public Health, University of Tampere, Tampere, Finland; ⁶ Department of Genetics, University of Leicester, Leicester, United Kingdom; ⁷ Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark; and ⁸ Section of Epidemiology, Institute of Cancer Research, Surrey, United Kingdom; and ⁹ Wake Forest University, School of Medicine, Brain Tumor Center of Excellence, Wake Forest, North Carolina

Requests for reprints: Judith Schwartzbaum, Division of Epidemiology and Biometrics, School of Public Health, Ohio State University, Starling-Loving Hall, 320 West Tenth Avenue, Columbus, OH 43210. Phone: 614-268-1548; Fax: 614-293-3937. E-mail: schwartzbaum.1{at}osu.edu

Previous studies found that allergies are inversely related to risk of glioma. In an earlier publication, using data from a Swedish case-control study, Schwartzbaum et al. report an inverse relation between risk of glioblastoma and four single nucleotide polymorphisms (SNP) on two genes [interleukin (IL)-4R, IL-13] that are associated with allergies. In addition, recent studies suggest that IL-4 and IL-13 induce cyclooxygenase-2 (COX-2) to resolve brain inflammation. To see whether previous Swedish results (110 cases, 430 controls) would be replicated, we estimated the association between glioblastoma and two IL-4R (rs1805015, rs1801275) and two IL-13 (rs20541, rs1800925) SNPs and their haplotypes and one COX-2 SNP (–765GC) using additional English, Danish, and Finnish data (217 cases, 1,171 controls). Among general population controls, we evaluated associations between these haplotypes, the COX-2 SNP, and self-reported allergies. Our data did not support our original observations relating individual IL-4R, IL-13, or COX-2 SNPs to glioblastoma risk. However, the T-G IL-4R haplotype was associated with glioblastoma risk (odds ratio, 2.26; 95% confidence interval, 1.13-4.52) and there was a suggestion of an inverse relation between this haplotype and hayfever prevalence among controls (odds ratio, 0.38; 95% confidence interval, 0.14-1.03). The lack of support for a link between four IL-4R and IL-13 SNPs and glioblastoma may reflect the absence of associations or may result from uncontrolled confounding by haplotypes related both to those that we examined and glioblastoma. Nonetheless, the association between the T-G IL-4R haplotype and glioblastoma risk may indicate a role of immune factors in glioblastoma development. (Cancer Epidemiol Biomarkers Prev 2007;16(11):2448–54)

This article has been cited by other articles:

				P. Rajaraman, A. V. Brenner, M. A. Butler, S. S. Wang, R. M. Pfeiffer, A. M. Ruder, M. S. Linet, M. Yeager, Z. Wang, N. Orr, et al. Common Variation in Genes Related to Innate Immunity and Risk of Adult Glioma Cancer Epidemiol. Biomarkers Prev., May 1, 2009; 18(5): 1651 - 1658. [Abstract] [Full Text] [PDF]

				M. E. Scheurer, R. El-Zein, P. A. Thompson, K. D. Aldape, V. A. Levin, M. R. Gilbert, J. S. Weinberg, and M. L. Bondy Long-term Anti-inflammatory and Antihistamine Medication Use and Adult Glioma Risk Cancer Epidemiol. Biomarkers Prev., May 1, 2008; 17(5): 1277 - 1281. [Abstract] [Full Text] [PDF]