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Cancer Epidemiology Biomarkers & Prevention 16, 2304, November 1, 2007. doi: 10.1158/1055-9965.EPI-07-0581
© 2007 American Association for Cancer Research

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A Prospective Study of Dietary Acrylamide Intake and the Risk of Endometrial, Ovarian, and Breast Cancer

Janneke G. Hogervorst1, Leo J. Schouten1, Erik J. Konings2, R. Alexandra Goldbohm3 and Piet A. van den Brandt1

1 Department of Epidemiology, Maastricht University, Maastricht, the Netherlands; 2 Food and Consumer Product Safety Authority, Region South, Department Research & Development, Eindhoven, the Netherlands; and 3 Department of Food and Chemical Risk Analysis, TNO Quality of Life, Zeist, the Netherlands

Requests for reprints: Janneke Hogervorst, Department of Epidemiology, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, the Netherlands. Phone: 31-433882391; Fax: 31-433884128. E-mail: JGF.Hogervorst{at}EPID.Unimaas.nl

Background: Acrylamide, a probable human carcinogen, was detected in various heat-treated carbohydrate-rich foods in 2002. The few epidemiologic studies done thus far have not shown a relationship with cancer. Our aim was to investigate the association between acrylamide intake and endometrial, ovarian, and breast cancer risk.

Methods: The Netherlands Cohort Study on diet and cancer includes 62,573 women, aged 55-69 years. At baseline (1986), a random subcohort of 2,589 women was selected using a case cohort analysis approach for analysis. The acrylamide intake of subcohort members and cases was assessed with a food frequency questionnaire and was based on chemical analysis of all relevant Dutch foods. Subgroup analyses were done for never-smokers to eliminate the influence of smoking; an important source of acrylamide.

Results: After 11.3 years of follow-up, 327, 300, and 1,835 cases of endometrial, ovarian, and breast cancer, respectively, were documented. Compared with the lowest quintile of acrylamide intake (mean intake, 8.9 µg/day), multivariable-adjusted hazard rate ratios (HR) for endometrial, ovarian, and breast cancer in the highest quintile (mean intake, 40.2 µg/day) were 1.29 [95% confidence interval (95% CI), 0.81-2.07; Ptrend = 0.18], 1.78 (95% CI, 1.10-2.88; Ptrend = 0.02), and 0.93 (95% CI, 0.73-1.19; Ptrend = 0.79), respectively. For never-smokers, the corresponding HRs were 1.99 (95% CI, 1.12-3.52; Ptrend = 0.03), 2.22 (95% CI, 1.20-4.08; Ptrend = 0.01), and 1.10 (95% CI, 0.80-1.52; Ptrend = 0.55).

Conclusions: We observed increased risks of postmenopausal endometrial and ovarian cancer with increasing dietary acrylamide intake, particularly among never-smokers. Risk of breast cancer was not associated with acrylamide intake. (Cancer Epidemiol Biomarkers Prev 2007;16(11):2304–13)




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Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
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Copyright © 2007 by the American Association for Cancer Research.