This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bunin, G. R. Articles by Cnaan, A. Search for Related Content PubMed PubMed Citation Articles by Bunin, G. R. Articles by Cnaan, A.

Maternal Supplement, Micronutrient, and Cured Meat Intake during Pregnancy and Risk of Medulloblastoma during Childhood: A Children's Oncology Group Study

Divisions of ¹ Oncology and ² Biostatistics and Epidemiology and ³ Departments of Pathology and Neurology, Children's Hospital of Philadelphia; ⁴ Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania and ⁵ Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee

Requests for reprints: Greta Bunin, c/o Donna Correia, CureSearch, Children's Oncology Group, 440 East Huntington Drive, Arcadia, CA 91006. Phone: 626-241-1509; Fax: 626-445-4334. E-mail: pubs{at}childrensoncologygroup.org

We conducted a case-control study of medulloblastoma/primitive neuroectodermal tumors of brain (PNET) to pursue findings related to vitamin and mineral supplements, micronutrients, and cured meat consumption during gestation. Mothers of 315 cases ages <6 years at diagnosis in 1991 to 1997 identified from the United States and Canada through the Children's Oncology Group and mothers of 315 controls selected by random-digit dialing were interviewed. In the periconception period of the index pregnancy, case mothers were less likely than control mothers to report use of multivitamins [adjusted odds ratio (OR), 0.7; 95% confidence interval (95% CI), 0.4-1.0; P = 0.08] and to be in the highest quartile of iron and folate intake from food and supplements combined (adjusted OR for iron, 0.5; 95% CI, 0.3-0.9; P_trend = 0.008; adjusted OR for folate, 0.5; 95% CI, 0.3-0.9; P_trend = 0.007). Case and control mothers had similar intakes of cured meats, although case mothers were more likely to have the combination of high cured meat and low vitamin C intake (OR, 1.5; 95% CI, 1.0-2.3; P = 0.08). The results of the study add to the evidence of a protective role for multivitamins, suggest a possible role for micronutrients early in pregnancy, and generally do not support an association between cured meats and medulloblastoma/PNET. (Cancer Epidemiol Biomarkers Prev 2006;15(9):1660–7)

This article has been cited by other articles:

				T. Bjorge, S. Cnattingius, R. T. Lie, S. Tretli, and A. Engeland Cancer Risk in Children with Birth Defects and in Their Families: A Population Based Cohort Study of 5.2 Million Children from Norway and Sweden Cancer Epidemiol. Biomarkers Prev., March 1, 2008; 17(3): 500 - 506. [Abstract] [Full Text] [PDF]

				B. N. Ames Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage PNAS, November 21, 2006; 103(47): 17589 - 17594. [Abstract] [Full Text] [PDF]