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MDM2 SNP309 and SNP354 Are Not Associated with Lung Cancer Risk

¹ Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, NIH; ² Section on Genomic Variation, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland; and ³ Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, District of Columbia

Requests for reprints: Curtis C. Harris, Laboratory of Human Carcinogenesis, National Cancer Institute, Room 3068, Building 37, 37 Convent Drive, Bethesda, MD 20892-4258. Phone: 301-496-2048; Fax: 301-496-0497. E-mail: curtis_harris{at}nih.gov

A single nucleotide polymorphism (SNP) in the MDM2 promoter (a T to G exchange at nucleotide 309) has been found to be associated with tumor formation. Publication of this null report is important because an association between MDM2 SNP309 and lung cancer was previously reported in two independent studies. Our findings suggest that MDM2 SNP309 is not a strong factor in lung carcinogenesis. In addition, this is the first MDM2 SNP309 report on a population consisting of Caucasians in the United States and African-Americans. A strength of the study design is that the controls consist of both population and hospital controls. (Cancer Epidemiol Biomarkers Prev 2006;15(8):1559–61)

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