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An Interlocker Concept of Carcinogenesis

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota

Requests for reprints: Lee W. Wattenberg, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455. Phone: 612-626-9113; Fax: 612-626-9198. E-mail: watte002{at}umn.edu

A critical feature in the sequence of events occurring during carcinogenesis is the development of irreversibility. The term "Interlocker" is used here to denote a mechanism by which irreversibility is brought about. The presentation focuses on conceptualizations of such processes. Two will be described below. (Cancer Epidemiol Biomarkers Prev 2006;15(8):1425–6)