This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kuijsten, A. Articles by Kampman, E. Search for Related Content PubMed PubMed Citation Articles by Kuijsten, A. Articles by Kampman, E.

Plasma Enterolignans Are Associated with Lower Colorectal Adenoma Risk

¹ Division of Human Nutrition, Wageningen University and ² RIKILT-Institute of Food Safety, Wageningen UR, Wageningen, the Netherlands

Requests for reprints: Peter Hollman, RIKILT-Institute of Food Safety, P.O. Box 230, 6700 AE, Wageningen, the Netherlands. Phone: 31-3174-75578; Fax: 31-3174-17717. E-mail: peter.hollman{at}wur.nl

Lignans are biphenolic compounds that occur in foods of plant origin such as whole grains, seeds, fruits and vegetables, and beverages, such as coffee and tea. Plant lignans are converted by intestinal bacteria into the enterolignans, enterodiol and enterolactone. Enterolignans possess several biological activities, whereby they may influence carcinogenesis. We studied the associations between plasma enterolignans and the risk of colorectal adenomas in a Dutch case-control study. Colorectal adenomas are considered to be precursors of colorectal cancer. Cases (n = 532) with at least one histologically confirmed colorectal adenoma and controls (n = 503) with no history of any type of adenoma were included. Plasma enterodiol and enterolactone concentrations were measured by liquid chromatography with tandem mass spectrometry. Associations were stronger for incident than for prevalent cases. When only incident cases (n = 262) were included, high compared to low plasma concentrations of enterodiol were associated with a reduction in colorectal adenoma risk after adjustment for confounding variables. Enterodiol odds ratios (95% confidence intervals) were 1.00, 0.69 (0.42-1.13), 0.60 (0.37-0.99), and 0.53 (0.32-0.88) with a significant trend (P = 0.01) through the quartiles. Although enterolactone plasma concentrations were 10-fold higher, enterolactone's reduction in risk was not statistically significant (P for trend = 0.09). Use of oral antibiotic therapy could decrease the plasma concentrations of enterolactone. Exclusion of antibiotic users resulted in similar odds ratios for both enterolignans, but the association for enterolactone became somewhat stronger (P = 0.05 versus P = 0.09). We observed a substantial reduction in colorectal adenoma risk among subjects with high plasma concentrations of enterolignans, in particular, enterodiol. These findings could be important in the prevention of colorectal adenomas. (Cancer Epidemiol Biomarkers Prev 2006;15(6):1132–6)

This article has been cited by other articles:

				A. Kuijsten, P. C. H. Hollman, H. C. Boshuizen, M. N. C. P. Buijsman, P. van 't Veer, F. J. Kok, I. C. W. Arts, and H. B. Bueno-de-Mesquita Plasma Enterolignan Concentrations and Colorectal Cancer Risk in a Nested Case-Control Study Am. J. Epidemiol., March 15, 2008; 167(6): 734 - 742. [Abstract] [Full Text] [PDF]

				I. E. J. Milder, A. Kuijsten, I. C. W. Arts, E. J. M. Feskens, E. Kampman, P. C. H. Hollman, and P. Van 't Veer Relation between Plasma Enterodiol and Enterolactone and Dietary Intake of Lignans in a Dutch Endoscopy-Based Population J. Nutr., May 1, 2007; 137(5): 1266 - 1271. [Abstract] [Full Text] [PDF]