This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mizoue, T. Articles by Tokunaga, S. Search for Related Content PubMed PubMed Citation Articles by Mizoue, T. Articles by Tokunaga, S.

Leanness, Smoking, and Enhanced Oxidative DNA Damage

¹ Department of Preventive Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; ² Department of Occupational Oncology, Institute of Industrial Ecological Sciences; and ³ Department of Urology, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan

Requests for reprints: Tetsuya Mizoue, Department of Preventive Medicine, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashiku, 812-8582 Fukuoka, Japan. Phone: 81-92-642-6111; Fax: 81-92-642-6115. E-mail: mizoue{at}phealth.med.kyushu-u.ac.jp

An increased risk of some forms of cancer, including lung cancer, among lean individuals has been consistent; however, there is a paucity of biological evidence supporting this relation. Subjects analyzed were 177 healthy Japanese workers who participated in a lifestyle intervention study. The levels of urinary 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative DNA damage, were measured using an automated high-pressure liquid chromatography and urinary creatinine levels were adjusted for before statistical analysis. A clear inverse association was found between body mass index (BMI) and 8-OHdG levels among smokers [Pearson correlation coefficient (r) = –0.48], and the association did not materially change after adjustment for potential confounding factors. In contrast, no apparent relation was observed between BMI and 8-OHdG levels among nonsmokers (r = –0.12), although lean nonsmokers had a slightly higher mean of 8-OHdG levels compared with nonlean nonsmokers. The interaction of smoking and BMI reached statistical significance (P = 0.04). Leanness may enhance oxidative DNA damage induced by smoking and thus serve as a marker of host susceptibility to smoking-related cancers. (Cancer Epidemiol Biomarkers Prev 2006;15(3):582–5)

This article has been cited by other articles:

				J. M. Battershill, K. Burnett, and S. Bull Factors affecting the incidence of genotoxicity biomarkers in peripheral blood lymphocytes: impact on design of biomonitoring studies Mutagenesis, November 1, 2008; 23(6): 423 - 437. [Abstract] [Full Text] [PDF]

				S. Otabe, X. Yuan, T. Fukutani, N. Wada, T. Hashinaga, H. Nakayama, N. Hirota, M. Kojima, and K. Yamada Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by high-calorie diet Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E210 - E218. [Abstract] [Full Text] [PDF]

				W Garavello, G Randi, C Bosetti, L Dal Maso, E Negri, L Barzan, S Franceschi, and C La Vecchia Body size and laryngeal cancer risk Ann. Onc., September 1, 2006; 17(9): 1459 - 1463. [Abstract] [Full Text] [PDF]