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1 Division of Epidemiology and Community Health, and 2 Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota; and 3 Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania
Requests for reprints: Aaron R. Folsom, Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454-1015. Phone: 612-626-8862; Fax: 612-624-0315. E-mail: folsom{at}epi.umn.edu
Background: We examined the potential association between physical activity and lung cancer in women.
Methods: In 1986, 36,929 women from Iowa, who were free of prior cancer, completed a questionnaire regarding physical activity, smoking, body mass index, and other life-style factors. Women were followed through 2002 for cancer incidence.
Results: After adjusting for potential confounders, women with high physical activity levels were less likely [hazard ratio, 0.77; 95% confidence intervals (CI), 0.64-0.94] to develop lung cancer than women with low activity levels. This hazard ratio was 0.72 (95% CI, 0.55-0.94) in current smokers and 0.63 (95% CI, 0.43-0.92) in former smokers, but was not significant in never smokers.
Conclusion: These results suggest that physical activity might reduce the risk of lung cancer in women who are current or former smokers. (Cancer Epidemiol Biomarkers Prev 2006;15(12):235964)
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