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The Development of Therapeutic and Preventive Vaccines for Gastric Cancer and Helicobacter pylori

Duke University Medical Center, Durham, North Carolina

Requests for reprints: Michael A. Morse, Duke University Medical Center, Box 2606, Durham, NC 27710. Phone: 919-684-6408; Fax: 919-681-7970. E-mail: morse004{at}mc.duke.edu

Gastric cancer is one of the most important worldwide public health problems. Convincing epidemiologic and etiologic associations have been made between the development of gastric cancer and infection with Helicobacter pylori. H. pylori not only has adapted to survive within the harsh environment of the stomach but also is able to modulate and avoid endogenous immune responses. The design and creation of efficacious vaccine strategies against H. pylori requires an understanding of the complex interactions that make up mucosal immunity. An effective vaccine strategy against H. pylori has the potential to affect significantly on population health worldwide.