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Role of Cytokine Polymorphisms in the Risk of Distal Gastric Cancer Development

Departments of ¹ Medicine and Microbiology, ² Microbiology, and ³ Medicine, New York University School of Medicine and ⁴ Departamento de Microbiologia, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Nuevo de Leon, Mexico

Requests for reprints: Guillermo I. Perez Perez, 6027W Veterans Affairs Medical Center, 423 East 23rd Street, New York, NY 10010. Phone: 212-263-4101; Fax: 212-263-4108. E-mail: perezg02{at}med.nyu.edu

We review the current information concerning the role of cytokine polymorphisms and the risk of develop distal gastric cancer in different populations. We have included populations colonized with Helicobacter pylori as well as populations without colonization. We found that the study of polymorphisms alone seems insufficient to assess gastric cancer risk and it is necessary to examine environmental factors in different ethnic groups and geographic areas along with the study of H. pylori strains to define better the risk factors associated with distal gastric cancer.