CEBP CTRC-AACR San Antonio Breast Cancer Symposium Translational Cancer Medicine 2008: Cancer Clinical Trials and Personalized Medicine
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mueller, A.
Right arrow Articles by Amieva, M. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mueller, A.
Right arrow Articles by Amieva, M. R.
Cancer Epidemiology Biomarkers & Prevention Vol. 14, 1859-1864, August 2005
© 2005 American Association for Cancer Research

Special Section

Helicobacter pylori and Gastric Cancer: What can be Learned by Studying the Response of Gastric Epithelial Cells to the Infection?

Anne Mueller, Stanley Falkow and Manuel R. Amieva

Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California

Requests for reprints: Anne Mueller, Department of Microbiology and Immunology, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305-5124. Phone: 650-723-2671; Fax: 650-723-1837. E-mail: muellera{at}stanford.edu

The development of gastric adenocarcinoma is closely linked to chronic infection with the bacterial pathogen Helicobacter pylori. One Helicobacter-specific virulence factor in particular, the CagA protein, has emerged as a main effector molecule in the interaction of H. pylori with gastric epithelial cells and has been implicated in gastric carcinogenesis. This review highlights the latest insights that have been gained into the pathogenesis of the disease by transcriptional profiling approaches studying gene expression in normal gastric tissue and gastric cancer tissue from human biopsy material as well as animal models of Helicobacter infection. The potential role of CagA as a bacterial oncoprotein is also discussed.




This article has been cited by other articles:


Home page
 Postgrad. Med. J.Home page
S K Tiwari, G Manoj, G V. Kumar, G Sivaram, S I Hassan, B Prabhakar, U Devi, S Jalaluddin, K Kumar, S Ahmed, et al.
Prognostic significance of genotyping Helicobacter pylori infection in patients in younger age groups with gastric cancer
Postgrad. Med. J., April 1, 2008; 84(990): 193 - 197.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
Copyright © 2005 by the American Association for Cancer Research.