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The Biology of Helicobacter pylori Infection, a Major Risk Factor for Gastric Adenocarcinoma

Departments of ¹ Molecular and Cell Biology and ² Microbiology, University of Washington School of Medicine; and ³ Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington

Requests for reprints: Nina Salama, Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, PO Box 19024, Seattle, WA 98109-1024. Phone: 206-667-1540; Fax: 206-667-6524. E-mail: nsalama{at}fhcrc.org

Helicobacter pylori infection of the human stomach is the most important risk factor for development of gastric cancer. Whereas persistent viral infection leads to a number of cancers, H. pylori was the first bacteria linked to a human cancer. The exact mechanisms that lead to cancer induction are not clear, but study of the bacterial factors important for colonization and the host responses to the infection are starting to yield important clues.

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				D. N. Baldwin, B. Shepherd, P. Kraemer, M. K. Hall, L. K. Sycuro, D. M. Pinto-Santini, and N. R. Salama Identification of Helicobacter pylori Genes That Contribute to Stomach Colonization Infect. Immun., February 1, 2007; 75(2): 1005 - 1016. [Abstract] [Full Text] [PDF]