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Common Polymorphisms in ERCC2 (Xeroderma pigmentosum D) are not Associated with Breast Cancer Risk

¹ Department of Oncology and ² Genetic Epidemiology Group, Cancer Research U.K.; ³ European Prospective Investigation of Cancer, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom; ⁴ Department of Obstetrics and Gynecology, Technical University Munich, Munich; ⁵ Division of Clinical Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany; ⁶ Cancer and Cell Biology Division, Queensland Institute for Medical Research, Queensland; ⁷ Centre for Genetic Epidemiology, The University of Melbourne, Melbourne; ⁸ Cancer Epidemiology Centre, The Council of Victoria, Carlton, Australia; and ⁹ Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand

Request for reprints: Paul D.P. Pharoah, Cancer Research U.K., Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, United Kingdom. Phone: 44-1223-740166; Fax: 44-1223-411609. E-mail: paul.pharoah{at}srl.cam.ac.uk

A substantial proportion of the familial risk of breast cancer may be due to genetic variants, each contributing a small effect. The protein encoded by ERCC2 is a key enzyme involved in nucleotide excision repair, in which gene defects could lead to cancer prone syndromes such as Xeroderma pigmentosum D. We have examined the association between single nucleotide polymorphisms in the ERCC2 gene and the incidence of invasive breast cancer in three case-control series, with a maximum of 3,634 patients and of 3,340 controls. None of the three single nucleotide polymorphisms were significantly associated with the incidence of breast cancer.

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