| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
1 Department of Epidemiology and Biostatistics, Nanjing Medical University School of Public Health, Nanjing, China and 2 Department of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston, Texas
Requests for reprints: Hongbing Shen, Department of Epidemiology and Biostatistics, Nanjing Medical University School of Public Health, 140 Hanzhong Road, 210029 Nanjing, China. Phone: 86-25-868-62747; Fax: 86-25-865-27613. E-mail: hbshen{at}njmu.edu.cn
Several potential functional polymorphisms (Arg194Trp, Arg280His, Arg399Gln) in the DNA base excision repair gene X-ray repair cross-complementing group 1 (XRCC1) have been implicated in cancer risk. Our meta-analysis on total of 11,957 cancer cases and 14,174 control subjects from 38 published case-control studies showed that the odds ratio (OR) for the variant genotypes (Trp/Trp + Arg/Trp) of the Arg194Trp polymorphism, compared with the wild-type homozygote (Arg/Arg), was 0.89 [95% confidence interval (95% CI), 0.81-0.98] for all tumor types without between-study heterogeneity. Similarly, the overall risk for the combined variant genotypes (His/His + Arg/His) of the Arg280His, compared with the wild homozygote (Arg/Arg), was 1.19 (95% CI, 1.00-1.42). However, there was no main effect in either recessive or dominant modeling for the Arg399Gln, and the variant Gln/Gln homozygote was not associated with overall cancer risk (OR, 1.01; 95% CI, 0.90-1.14). The analyses suggest that XRCC1 Arg194Trp, Arg280His polymorphisms may be biomarkers of cancer susceptibility and a single larger study with thousands of subjects and tissue-specific biochemical and biological characterization is warranted to further evaluate potential gene-to-gene and gene-to-environment interactions on XRCC1 polymorphisms and cancer risk.
This article has been cited by other articles:
|
|
 |
|
  N. M Akulevich, V. A Saenko, T. I Rogounovitch, V. M Drozd, E. F Lushnikov, V. K Ivanov, N. Mitsutake, R. Kominami, and S. Yamashita Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma Endocr. Relat. Cancer, June 1, 2009; 16(2): 491 - 503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Vineis, M. Manuguerra, F. K. Kavvoura, S. Guarrera, A. Allione, F. Rosa, A. Di Gregorio, S. Polidoro, F. Saletta, J. P. A. Ioannidis, et al. A Field Synopsis on Low-Penetrance Variants in DNA Repair Genes and Cancer Susceptibility J Natl Cancer Inst, January 7, 2009; 101(1): 24 - 36. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Maynard, S. H. Schurman, C. Harboe, N. C. de Souza-Pinto, and V. A. Bohr Base excision repair of oxidative DNA damage and association with cancer and aging Carcinogenesis, January 1, 2009; 30(1): 2 - 10. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bag and N. Bag Target Sequence Polymorphism of Human Manganese Superoxide Dismutase Gene and Its Association with Cancer Risk: A Review Cancer Epidemiol. Biomarkers Prev., December 1, 2008; 17(12): 3298 - 3305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Lao, W. Gu, and Q. Huang A meta-analysis on XRCC1 R399Q and R194W polymorphisms, smoking and bladder cancer risk Mutagenesis, November 1, 2008; 23(6): 523 - 532. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F.-Y. Chiang, C.-W. Wu, P.-J. Hsiao, W.-R. Kuo, K.-W. Lee, J.-C. Lin, Y.-C. Liao, and S.-H. H. Juo Association between Polymorphisms in DNA Base Excision Repair Genes XRCC1, APE1, and ADPRT and Differentiated Thyroid Carcinoma Clin. Cancer Res., September 15, 2008; 14(18): 5919 - 5924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Hoskins, E. Marcuello, A. Altes, S. Marsh, T. Maxwell, D. J. Van Booven, L. Pare, R. Culverhouse, H. L. McLeod, and M. Baiget Irinotecan Pharmacogenetics: Influence of Pharmacodynamic Genes Clin. Cancer Res., March 15, 2008; 14(6): 1788 - 1796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Mateuca, M. Roelants, G. Iarmarcovai, P. V. Aka, L. Godderis, A. Tremp, S. Bonassi, M. Fenech, J.-L. Berge-Lefranc, and M. Kirsch-Volders hOGG1326, XRCC1399 and XRCC3241 polymorphisms influence micronucleus frequencies in human lymphocytes in vivo Mutagenesis, January 1, 2008; 23(1): 35 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-Y. Huang, Y.-T. Gao, A. Rashid, L. C. Sakoda, J. Deng, M.-C. Shen, B.-S. Wang, T.-Q. Han, B.-H. Zhang, B. E. Chen, et al. Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China Carcinogenesis, January 1, 2008; 29(1): 100 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-P. Huang, C.-Y. Huang, J.-S. Wang, C.-C. Liu, Y.-S. Pu, H.-J. Yu, C.-C. Yu, T. T. Wu, C.-H. Huang, W.-J. Wu, et al. Prognostic Significance of p53 and X-ray Repair Cross-complementing Group 1 Polymorphisms on Prostate-Specific Antigen Recurrence in Prostate Cancer Post Radical Prostatectomy Clin. Cancer Res., November 15, 2007; 13(22): 6632 - 6638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. V. Breton, W. Zhou, M. L. Kile, E.A. Houseman, Q. Quamruzzaman, M. Rahman, G. Mahiuddin, and D. C. Christiani Susceptibility to arsenic-induced skin lesions from polymorphisms in base excision repair genes Carcinogenesis, July 1, 2007; 28(7): 1520 - 1525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. F. Giachino, P. Ghio, S. Regazzoni, G. Mandrile, S. Novello, G. Selvaggi, D. Gregori, M. DeMarchi, and G. V. Scagliotti Prospective Assessment of XPD Lys751Gln and XRCC1 Arg399Gln Single Nucleotide Polymorphisms in Lung Cancer Clin. Cancer Res., May 15, 2007; 13(10): 2876 - 2881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Brem, D. G. Cox, B. Chapot, N. Moullan, P. Romestaing, J.-P. Gerard, P. Pisani, and J. Hall The XRCC1 -77T->C variant: haplotypes, breast cancer risk, response to radiotherapy and the cellular response to DNA damage Carcinogenesis, December 1, 2006; 27(12): 2469 - 2474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Landi, F. Gemignani, F. Canzian, V. Gaborieau, R. Barale, D. Landi, N. Szeszenia-Dabrowska, D. Zaridze, J. Lissowska, P. Rudnai, et al. DNA Repair and Cell Cycle Control Genes and the Risk of Young-Onset Lung Cancer. Cancer Res., November 15, 2006; 66(22): 11062 - 11069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang, P. A. Newcomb, K. M. Egan, L. Titus-Ernstoff, S. Chanock, R. Welch, L. A. Brinton, J. Lissowska, A. Bardin-Mikolajczak, B. Peplonska, et al. Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer. Cancer Epidemiol. Biomarkers Prev., February 1, 2006; 15(2): 353 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Paz-Elizur, D. E. Brenner, and Z. Livneh Interrogating DNA Repair in Cancer Risk Assessment Cancer Epidemiol. Biomarkers Prev., July 1, 2005; 14(7): 1585 - 1587. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
