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A DNA Pooling Strategy for Family-Based Association Studies

Graduate Institute of Epidemiology, College of Public Health, National Taiwan University

Requests for reprints: Wen-Chung Lee, No. 1, Jen-Ai Road, 1st Section, Taipei, Taiwan. Phone: 886-2-23511955; Fax: 886-2-23511955. E-mail: wenchung{at}ha.mc.ntu.edu.tw

Genome-wide association scans for disease susceptibility genes of complex diseases require genotyping on a massive scale. A DNA pooling strategy for family-based association studies is described, which is robust to population stratification biases and to errors in pooling. It can achieve a statistical efficiency of 0.95 with 1 of 8 or fewer genotyping efforts, and an efficiency of 0.90 with 1 of 16 or fewer efforts compared with individual genotyping. The pooling method described in this article provides a tradeoff between genotyping efforts and subject recruitment efforts.