This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bosetti, C. Articles by La Vecchia, C. Search for Related Content PubMed PubMed Citation Articles by Bosetti, C. Articles by La Vecchia, C.

Flavonoids and Breast Cancer Risk in Italy

¹ Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy; ² Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano (PN), Italy; ³ Instituto di Igiene ed Epidemiologia, Policlinico Universitario di Udine, Udine, Italy; ⁴ Divisione di Epidemiologia e Biostatistica, Istituto Europeo di Oncologia, Milan, Italy; ⁵ Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece; ⁶ International Agency for Research on Cancer, Lyon, France; ⁷ Servizio di Epidemiologia, Istituto Tumori "Fondazione Pascale", Naples, Italy; ⁸ Frances Stern Nutrition Center, Tufts-New England Medical Center, Boston, Massachusetts; ⁹ Schools of Medicine, Nutrition, and the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts; ¹⁰ Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy; and ¹¹ Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy

Requests for reprints: Cristina Bosetti, Istituto di Ricerche Farmacologiche "Mario Negri", Via Eritrea 62-20157 Milan, Italy. Phone: 39-2390-14526; Fax: 39-2332-00231. E-mail: bosetti{at}marionegri.it

Few epidemiologic studies have investigated the potential relation between flavonoids and breast cancer risk. We have applied recently published data on the composition of foods and beverages in terms of six principal classes of flavonoids (i.e., flavanones, flavan-3-ols, flavonols, flavones, anthocyanidines, and isoflavones) on dietary information collected in a large-case control study of breast cancer conducted in Italy between 1991 and 1994. The study included 2,569 women with incident, histologically confirmed breast cancer, and 2,588 hospital controls. Odds ratios (OR) and 95% confidence intervals were estimated by multiple logistic regression models. After allowance for major confounding factors and energy intake, a reduced risk of breast cancer was found for increasing intake of flavones (OR, 0.81, for the highest versus the lowest quintile; P-trend, 0.02), and flavonols (OR, 0.80; P-trend, 0.06). No significant association was found for other flavonoids, including flavanones (OR, 0.95), flavan-3-ols (OR, 0.86), anthocyanidins (OR, 1.09), as well as for isoflavones (OR, 1.05). The findings of this large study of an inverse association between flavones and breast cancer risk confirm the results of a Greek study.

This article has been cited by other articles:

				B. N. Fink, S. E. Steck, M. S. Wolff, J. A. Britton, G. C. Kabat, M. M. Gaudet, P. E. Abrahamson, P. Bell, J. C. Schroeder, S. L. Teitelbaum, et al. Dietary Flavonoid Intake and Breast Cancer Survival among Women on Long Island Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2285 - 2292. [Abstract] [Full Text] [PDF]

				M. Rossi, W. Garavello, R. Talamini, E. Negri, C. Bosetti, L. Dal Maso, P. Lagiou, A. Tavani, J. Polesel, L. Barzan, et al. Flavonoids and the Risk of Oral and Pharyngeal Cancer: A Case-Control Study from Italy Cancer Epidemiol. Biomarkers Prev., August 1, 2007; 16(8): 1621 - 1625. [Abstract] [Full Text] [PDF]

				S. Shukla, G. T. MacLennan, C. A. Flask, P. Fu, A. Mishra, M. I. Resnick, and S. Gupta Blockade of {beta}-Catenin Signaling by Plant Flavonoid Apigenin Suppresses Prostate Carcinogenesis in TRAMP Mice Cancer Res., July 15, 2007; 67(14): 6925 - 6935. [Abstract] [Full Text] [PDF]

				W Garavello, M Rossi, J. McLaughlin, C Bosetti, E Negri, P Lagiou, R Talamini, S Franceschi, M Parpinel, L Dal Maso, et al. Flavonoids and laryngeal cancer risk in Italy Ann. Onc., June 1, 2007; 18(6): 1104 - 1109. [Abstract] [Full Text] [PDF]

				J. W. Erdman Jr., D. Balentine, L. Arab, G. Beecher, J. T. Dwyer, J. Folts, J. Harnly, P. Hollman, C. L. Keen, G. Mazza, et al. Flavonoids and Heart Health: Proceedings of the ILSI North America Flavonoids Workshop, May 31-June 1, 2005, Washington, DC J. Nutr., March 1, 2007; 137(3): 718S - 737S. [Abstract] [Full Text] [PDF]

				B. N. Fink, S. E. Steck, M. S. Wolff, J. A. Britton, G. C. Kabat, J. C. Schroeder, S. L. Teitelbaum, A. I. Neugut, and M. D. Gammon Dietary Flavonoid Intake and Breast Cancer Risk among Women on Long Island Am. J. Epidemiol., March 1, 2007; 165(5): 514 - 523. [Abstract] [Full Text] [PDF]

				C. Bosetti, M. Rossi, J. K. McLaughlin, E. Negri, R. Talamini, P. Lagiou, M. Montella, V. Ramazzotti, S. Franceschi, and C. LaVecchia Flavonoids and the Risk of Renal Cell Carcinoma Cancer Epidemiol. Biomarkers Prev., January 1, 2007; 16(1): 98 - 101. [Abstract] [Full Text] [PDF]

				M. Rossi, E. Negri, R. Talamini, C. Bosetti, M. Parpinel, P. Gnagnarella, S. Franceschi, L. Dal Maso, M. Montella, A. Giacosa, et al. Flavonoids and colorectal cancer in Italy. Cancer Epidemiol. Biomarkers Prev., August 1, 2006; 15(8): 1555 - 1558. [Abstract] [Full Text] [PDF]

				R. Uauy and N. Solomons Diet, Nutrition, and the Life-Course Approach to Cancer Prevention J. Nutr., December 1, 2005; 135(12): 2934S - 2945S. [Abstract] [Full Text] [PDF]