| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
1 Division of Gastroenterology, Department of Therapeutic Medicine, Nagoya University Graduate School of Medicine and 2 Department of Endoscopy, Nagoya University Hospital, Nagoya, Japan
Requests for reprints: Naoki Ohmiya, Division of Gastroenterology, Department of Therapeutic Medicine, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, Aichi, 466-8550 Japan. Phone: 81-52-744-2172; Fax: 81-52-744-2180. E-mail: nohmiya{at}med.nagoya-u.ac.jp
Host genetic susceptibility may influence gastric carcinogenesis caused by Helicobacter pylori infection. We aimed to clarify the relationship of interleukin (IL)-8 polymorphism with the risk of atrophic gastritis and gastric cancer. We examined IL-8 –251 T > A, IL-1B –511 C > T, and IL-1RN intron 2 polymorphisms in 252 healthy controls, 215 individuals with atrophic gastritis, and 396 patients with gastric cancer. We also investigated the effect of the IL-8 polymorphism on IL-8 production and histologic degree of gastritis in noncancerous gastric mucosa. Although no correlation was found in the analysis of the IL-1B and IL-1RN polymorphisms, IL-8 –251 A/A genotype held a higher risk of atrophic gastritis [odds ratio (OR), 2.35; 95% confidence interval (CI), 1.12-4.94] and gastric cancer (OR, 2.22; 95% CI, 1.08-4.56) compared with the T/T genotype. We also found that the A/A genotype increased the risk of upper-third location (OR, 3.66; 95% CI, 1.46-9.17), diffuse (OR, 2.79; 95% CI, 1.21-6.39), poorly differentiated (OR, 2.70; 95% CI, 1.14-6.38), lymph node (OR, 2.50; 95% CI, 1.01-6.20), and liver metastasis (OR, 5.63; 95% CI, 1.06-30.04), and p53-mutated (OR, 1.91; 95% CI, 1.13-3.26) subtypes of gastric cancer. The A/A and A/T genotypes were significantly associated with higher levels of IL-8 protein compared with the T/T genotype. Neutrophil infiltration score was significantly higher in the A/A genotype than in the T/T genotype. In conclusion, we showed that the IL-8 –251 T > A polymorphism is associated with higher expression of IL-8 protein, more severe neutrophil infiltration, and increased risk of atrophic gastritis and gastric cancer.
This article has been cited by other articles:
|
|
 |
|
  G. Lurje, W. Zhang, A. M. Schultheis, D. Yang, S. Groshen, A. E. Hendifar, H. Husain, M. A. Gordon, F. Nagashima, H. M. Chang, et al. Polymorphisms in VEGF and IL-8 predict tumor recurrence in stage III colon cancer Ann. Onc., June 11, 2008; (2008) mdn368v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. R. Amura, K. S. Brodsky, B. Gitomer, K. McFann, G. Lazennec, M. T. Nichols, A. Jani, R. W. Schrier, and R. Brian Doctor CXCR2 agonists in ADPKD liver cyst fluids promote cell proliferation Am J Physiol Cell Physiol, March 1, 2008; 294(3): C786 - C796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-Y. Tsai, J.-M. Lin, L. Wan, H.-J. Lin, Y. Tsai, C.-C. Lee, C.-H. Tsai, F.-J. Tsai, and S.-H. Tseng Interleukin Gene Polymorphisms in Age-Related Macular Degeneration Invest. Ophthalmol. Vis. Sci., February 1, 2008; 49(2): 693 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Kamangar, C. Cheng, C. C. Abnet, and C. S. Rabkin Interleukin-1B Polymorphisms and Gastric Cancer Risk--A Meta-analysis. Cancer Epidemiol. Biomarkers Prev., October 1, 2006; 15(10): 1920 - 1928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ohmiya, A. Taguchi, N. Mabuchi, A. Itoh, Y. Hirooka, Y. Niwa, and H. Goto MDM2 Promoter Polymorphism Is Associated With Both an Increased Susceptibility to Gastric Carcinoma and Poor Prognosis J. Clin. Oncol., September 20, 2006; 24(27): 4434 - 4440. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Cell Growth & Differentiation |
