This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kelsey, K. T. Articles by Karagas, M. R. Search for Related Content PubMed PubMed Citation Articles by Kelsey, K. T. Articles by Karagas, M. R.

A Population-Based Case-Control Study of the XRCC1 Arg399Gln Polymorphism and Susceptibility to Bladder Cancer

Departments of ¹ Genetics and Complex Diseases and ² Environmental Health, Harvard School of Public Health, Boston, Massachusetts and ³ Section of Biostatistics and Epidemiology, Department of Family and Community Medicine, Dartmouth Medical School, Hanover, New Hampshire

Requests for reprints: Karl T. Kelsey, Department of Genetics and Complex Diseases, Harvard School of Public Health, Building 1, Room 607, 665 Huntington Avenue, Boston, MA 02115. Phone: 617-432-3313; Fax: 617-432-0107. E-mail: kelsey{at}hsph.harvard.edu

Cigarette smoking is the major cause of bladder cancer. Constituents in tobacco smoke can induce oxidative DNA damage requiring base excision repair. The Arg399Gln polymorphism in the DNA base excision repair gene XRCC1 is associated with several phenotypic markers of reduced DNA repair capacity. Results from several epidemiologic studies suggest that the Arg399Gln polymorphism may influence susceptibility to several cancers including bladder cancer; however, data from large population-based studies are lacking. In a population-based case-control study from New Hampshire, we observed a reduced risk among those homozygous for the Arg399Gln XRCC1 variant polymorphism compared with those with one or two wild-type alleles (odds ratio 0.6, 95% confidence interval 0.4-1.0). There was no indication of a gene-environment interaction between cigarette smoking and the variant genotype. Our data are consistent with a potential role of the XRCC1 Arg399Gln polymorphism in bladder cancer susceptibility and further suggest that there may be DNA lesions important in bladder carcinogenesis, repaired by the base excision repair mechanism, that are not directly associated with tobacco smoking.

This article has been cited by other articles:

				K. Arizono, Y. Osada, and Y. Kuroda DNA Repair Gene hOGG1 Codon 326 and XRCC1 Codon 399 Polymorphisms and Bladder Cancer Risk in a Japanese Population Jpn. J. Clin. Oncol., March 1, 2008; 38(3): 186 - 191. [Abstract] [Full Text] [PDF]

				M. Huang, C. P. Dinney, X. Lin, J. Lin, H. B. Grossman, and X. Wu High-Order Interactions among Genetic Variants in DNA Base Excision Repair Pathway Genes and Smoking in Bladder Cancer Susceptibility Cancer Epidemiol. Biomarkers Prev., January 1, 2007; 16(1): 84 - 91. [Abstract] [Full Text] [PDF]

				A. S. Andrew, H. H. Nelson, K. T. Kelsey, J. H. Moore, A. C. Meng, D. P. Casella, T. D. Tosteson, A. R. Schned, and M. R. Karagas Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility Carcinogenesis, May 1, 2006; 27(5): 1030 - 1037. [Abstract] [Full Text] [PDF]

				R. J. Hung, J. Hall, P. Brennan, and P. Boffetta Genetic Polymorphisms in the Base Excision Repair Pathway and Cancer Risk: A HuGE Review Am. J. Epidemiol., November 15, 2005; 162(10): 925 - 942. [Abstract] [Full Text] [PDF]

				G. Matullo, S. Guarrera, C. Sacerdote, S. Polidoro, L. Davico, S. Gamberini, M. Karagas, G. Casetta, L. Rolle, A. Piazza, et al. Polymorphisms/Haplotypes in DNA Repair Genes and Smoking: A Bladder Cancer Case-Control Study Cancer Epidemiol. Biomarkers Prev., November 1, 2005; 14(11): 2569 - 2578. [Abstract] [Full Text] [PDF]

				A.-F. Dekairelle, B. Tombal, J.-P. Cosyns, and J.-L. Gala Assessment of the Transcriptional Activity of p53 Improves the Prediction of Recurrence in Superficial Transitional Cell Carcinoma of the Bladder Clin. Cancer Res., July 1, 2005; 11(13): 4724 - 4732. [Abstract] [Full Text] [PDF]

				Y.-T. Jeon, J. W. Kim, N.-H. Park, Y.-S. Song, S.-B. Kang, and H.-P. Lee DNA repair gene XRCC1 Arg399Gln polymorphism is associated with increased risk of uterine leiomyoma Hum. Reprod., June 1, 2005; 20(6): 1586 - 1589. [Abstract] [Full Text] [PDF]

				R. Brem and J. Hall XRCC1 is required for DNA single-strand break repair in human cells Nucleic Acids Res., May 2, 2005; 33(8): 2512 - 2520. [Abstract] [Full Text] [PDF]