| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
1 Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland, Australia; 2 Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts; 3 Department of Pathology, Harvard Medical School and Beth-Israel Deaconess Medical Center, Boston, Massachusetts; and Departments of 4 Epidemiology and 5 Nutrition, Harvard School of Public Health, Boston, Massachusetts
Requests for reprints: Graham A. Colditz, Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115. E-mail: graham.colditz{at}channing.harvard.edu
Much attention has been paid to the relation between diet and breast cancer risk. Because benign breast disease (BBD), particularly atypical hyperplasia (AH), is a marker of increased breast cancer risk, studies of diet and BBD may provide evidence about the effect of diet at an early stage in the process of breast carcinogenesis. We evaluated the relationship between fat, fiber, antioxidant and caffeine intake and incidence of non-proliferative BBD, proliferative BBD without atypia and AH in the Nurses' Health Study II. We calculated rate ratios (RR) and 95% confidence intervals (95% CI) for each quartile of energy-adjusted intake using the lowest quartile as reference. There was no increase in risk of BBD with increasing fat intake, rather increasing vegetable fat was associated with a significant reduction in the rate of proliferative BBD without atypia. There was no significant association between any type of BBD and micronutrient intake. High caffeine consumption was positively associated (RR = 2.46, 95% CI 1.11-5.49 for the highest quartile), and use of multivitamin supplements inversely associated (RR = 0.57, 95% CI 0.33-0.98) with risk of AH although these analyses were based on small numbers. These data do not support the hypothesis that higher fat consumption increases risk of BBD, with or without atypia, and also provide little evidence for a major role of antioxidants in the development of breast disease. They do, however, raise the possibility that high caffeine intake may increase, and use of vitamin supplements may decrease risk of developing AH.
This article has been cited by other articles:
|
|
 |
|
  T. J. Jorgensen, K. J. Helzlsouer, S. C. Clipp, J. H. Bolton, R. M. Crum, and K. Visvanathan DNA Repair Gene Variants Associated with Benign Breast Disease in High Cancer Risk Women Cancer Epidemiol. Biomarkers Prev., January 1, 2009; 18(1): 346 - 350. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Shannon, I. B King, J. W Lampe, D. L. Gao, R. M Ray, M.-G. Lin, H. Stalsberg, and D. B Thomas Erythrocyte fatty acids and risk of proliferative and nonproliferative fibrocystic disease in women in Shanghai, China Am. J. Clinical Nutrition, January 1, 2009; 89(1): 265 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ishitani, J. Lin, J. E. Manson, J. E. Buring, and S. M. Zhang Caffeine Consumption and the Risk of Breast Cancer in a Large Prospective Cohort of Women Arch Intern Med, October 13, 2008; 168(18): 2022 - 2031. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. E. Rohan, A. Negassa, B. Caan, R. T. Chlebowski, J. D. Curb, M. Ginsberg, D. S. Lane, M. L. Neuhouser, J. M. Shikany, S. Wassertheil-Smoller, et al. Low-Fat Dietary Pattern and Risk of Benign Proliferative Breast Disease: A Randomized, Controlled Dietary Modification Trial Cancer Prevention Research, September 1, 2008; 1(4): 275 - 284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Baker, G. P. Beehler, A. C. Sawant, V. Jayaprakash, S. E. McCann, and K. B. Moysich Consumption of Coffee, but Not Black Tea, Is Associated with Decreased Risk of Premenopausal Breast Cancer J. Nutr., January 1, 2006; 136(1): 166 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Baer, S. J. Schnitt, J. L. Connolly, C. Byrne, W. C. Willett, B. Rosner, and G. A. Colditz Early Life Factors and Incidence of Proliferative Benign Breast Disease Cancer Epidemiol. Biomarkers Prev., December 1, 2005; 14(12): 2889 - 2897. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
