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Reliability and Validity of Opiate Use Self-Report in a Population at High Risk for Esophageal Cancer in Golestan, Iran

¹ Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland; ² International Agency for Research on Cancer and ³ Department of Biochemistry, Eduard Herriot Hospital, Lyon, France; and ⁴ Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Requests for reprints: Christian C. Abnet, Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, 6116 Executive Boulevard, Room 705, Bethesda, MD 20892. Phone: 301-594-1511; Fax: 301-435-8644. E-mail: abnetc{at}mail.nih.gov

Objective: To assess the reliability and validity of self-reported opium use in a rural Iranian population at high risk for esophageal cancer in preparation for a large cohort study. Method: 1,057 subjects ages 33 to 84 years were recruited from Gonbad city and three surrounding villages in Golestan province of Iran and completed a questionnaire and provided biological samples. The history and duration of using opium, smoking tobacco, chewing nass, and drinking alcohol were measured by questionnaire in the entire cohort. A subgroup of 130 people was reinterviewed after 2 months to assess reliability. Validity of the opium question was assessed by comparing the questionnaire responses with the presence of codeine and morphine in the urine of 150 selected subjects. Results: Self-reported opiate use is reliable and valid in this population. The reliability of ever opium use and duration of opium use had 's of 0.96 and 0.74, respectively. The validity of self-reported opium use was also high. Using urine codeine or morphine as the gold standard for use of opium, self-report had a sensitivity of 0.93 and a specificity of 0.89. Conclusions: The self-reported use of opium can provide a reliable and valid measurement in this population and will be useful for studying associations between opium use and occurrence of esophageal cancer and other diseases.